DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and SmydA-3

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001260366.1	Gene:	SmydA-3 / 34502	FlyBaseID:	FBgn0262599	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	92/419 - (21%)
Similarity:	154/419 - (36%)	Gaps:	108/419 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 GRFARASADVKPGEELLVER-PFVSVLLEKFAKTHCENCFMRTVVPVACPRC------ADVLYCS 307
            ||:..|...:: |..||:|. ||.       ....|..       ||.|..|      .:...||
  Fly    21 GRYLVAKGAIR-GHGLLIEELPFA-------VGPKCNG-------PVVCLGCYEPNPDPEEELCS 70

  Fly   308 E-------QCREEASKKYHKYECG----------IVPIIWRSGASINNHIALRIIASKPLDYFLK 355
            |       :|.::|...:.:.||.          .:|    ||   :.|       ...||..:.
  Fly    71 ECGWPLCVECAQQADNAHFRLECSQLKDARARFFRLP----SG---SRH-------CPQLDCIMP 121

  Fly   356 LKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQH---VLMARFLTNCLRAGGYFGS 417
            |:..:.:|..||:..:       .||.:|.|:.|||......|   |.:|::|....:....|..
  Fly   122 LRVLLAKEANPERWDN-------EVAPMEHHKEERQRDADVWHADRVNIAQYLRGPCQLANRFSE 179

  Fly   418 EPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPGVV 482
            |           |:::.:..::.|..|          .|....:....::|...:..|:|.|...
  Fly   180 E-----------LIMQVVGVLEVNAFE----------ARSPKGYPLRCLFPYTGILAHNCVPNTS 223

  Fly   483 RYF---RGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDACIDNWPKF 544
            |..   .|..|.:.::..:|.|.|::.:|  .||.|..::||..||...:|.|.|:.|:|.
  Fly   224 RSIYPSEGYKIRLRAMVDLEEGQPLHHSY--TYTLDGTAQRQKHLKQGKFFTCQCERCLDP---- 282

  Fly   545 DDLPRDVIRFRCDAPNNCSAVIEVP--PSCNDFMVKCVTCGEITNILKGLKVMQD-------TEM 600
            .:|.......:|   ..|:...:||  |:..|....|..||..|:....|.::|.       .:.
  Fly   283 TELGTHFSSLKC---GQCAEGFQVPRQPTEPDTSWNCANCGSDTSNADALAMLQSLQSEVNAVQA 344

  Fly   601 MTRTAKRLYETGEYPKALAKFVDLIRIMY 629
            :...||||   .|..:.|.|:..|:..::
  Fly   345 LPMAAKRL---EEIERLLRKYKSLLHPLH 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	10/51 (20%)
SmydA-3	NP_001260366.1	SET	<207..252	CDD:250181	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810