DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and smyd1a

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_991103.2	Gene:	smyd1a / 321245	ZFINID:	ZDB-GENE-030131-9825	Length:	485	Species:	Danio rerio

Alignment Length:	435	Identity:	91/435 - (20%)
Similarity:	153/435 - (35%)	Gaps:	135/435 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 EGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPVACPRCADVLYCSEQCREE 313
            :||..|.:.|:..||.:..|..|.:|:|:..:...|.:||.|.|.|..|.:|....||...| :.
Zfish    17 KGRGLRGTRDLSAGEVVFAEASFAAVVLDSLSLQVCHSCFRRQVNPHRCAQCKFAHYCDRTC-QR 80

  Fly   314 ASKKYHKYECG---------------IVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTID-- 361
            |:...|:.||.               :..|:||    |..|..|  ::...|       .|:|
Zfish    81 AAWDEHRKECSAIRNIGKAPNENVRLVARILWR----IQKHTGL--VSDSQL-------TTLDML 132

  Fly   362 ----EELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGGYFGSEPK-- 420
                ..:|||.|..|..|                         :..|.|       |:..:.|
Zfish   133 EDHLSRMTPEDLKELKVD-------------------------VKTFYT-------YWPKKSKAV 165

  Fly   421 -PDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPGV--- 481
             .|.||.:..::               ..:.|:.|.:.....:|..::|.|.|.||.|.|..
Zfish   166 GEDYVSHLFGVI---------------SCNGFTLSDQRGLQSVGIGLFPNLCLVNHDCWPNCTVI 215

  Fly   482 ----------VRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDA 536
                      ..:.....|.:.::.||.||..:..:|....:..  ::||..|:..|:|:|.|:.
Zfish   216 LNHGDQSALDASFHSSRRIELRALEPISAGQELTVSYVDFLSVS--TDRQRLLQQQYYFDCKCEH 278

  Fly   537 CIDNWPKFDDLPRDVIRFRCDAPNNCSAVIEVPPSCNDFMVKCVTCGEITNILKGLKVMQDTEMM 601
            |: |..| |:| ...::...|.....:.|::   ...||.::.:           :|:
Zfish   279 CV-NGTK-DEL-MTAVKPTEDGKQPSAEVVK---QLTDFSLQAL-----------VKI------- 319

  Fly   602 TRTAKRLYETGEYPKALAKFVDLIRIMYEVLAPPFPDFCESQQHL 646
                       |..:|...|.::|||..|.|....|.|.::..|:
Zfish   320 -----------EAARAQGNFHEVIRICRECLEKQDPVFADTNVHV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	13/38 (34%)
smyd1a	NP_991103.2	zf-MYND	52..90	CDD:280009	13/38 (34%)
smyd1a	NP_991103.2	SET	<203..252	CDD:279228	10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810