DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smyd4-3 and Smyd4

DIOPT Version :10

Sequence 1:NP_725048.1 Gene:Smyd4-3 / 36234 FlyBaseID:FBgn0033633 Length:660 Species:Drosophila melanogaster
Sequence 2:NP_001096081.1 Gene:Smyd4 / 319822 MGIID:2442796 Length:799 Species:Mus musculus


Alignment Length:673 Identity:155/673 - (23%)
Similarity:260/673 - (38%) Gaps:130/673 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 KERATSAFKAKKWLEAMMLYTRSYVALPSENVAEIRVVLANRSATLYHMQKYQECLIDIKRALDL 142
            :|.....|:.|::.:|.:||::. |:....|..:|.:..|||||.|:|:.:|:.||.||..|...
Mouse    72 REEGNRKFQEKEYTDAAVLYSKG-VSHSRPNTEDISLCYANRSAALFHLGQYEACLKDIVEAGMH 135

  Fly   143 SYSKDLIYKLYERQARCYM---ALKDYPHTIDSFKKCITAMDDSTLASDKRAKLNLDAMTMIKML 204
            .|.:.|..|:..|:..|.:   .|::...||...:..:||.....|:|             .::|
Mouse   136 GYPERLQPKMMVRKTECLVNLGRLQEARQTISDLESSLTAKPTLVLSS-------------YQIL 187

  Fly   205 QNDPRTAKQEAKQQKQKIALDQAKPVKLENEF--------------VSPLVRIDSNRQEGRFARA 255
            |.:.:..|.:.   ::|..|.:..|..|.|.|              .|..|.:.::..:||...|
Mouse   188 QRNVQHLKIKI---QEKETLPEPIPAALTNAFEDIALGEENTQISGASLSVSLCTHPLKGRHLVA 249

  Fly   256 SADVKPGEELLVERPFVSVLLE-KFAKTH-----------------CENCFMRTVVPVACPRCAD 302
            :.|:.|||.|:.|..|||||:. :..:.|                 |..|...|:..|.|..|:.
Mouse   250 TKDILPGELLVKEDAFVSVLIPGEMPRPHHCLENKWDTRVTSGDLYCHRCLKHTLATVPCGSCSY 314

  Fly   303 VLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRI-------------------IAS- 347
            ..|||::|.::|...||..||.:..::...|  :..|:|||:                   :.| 
Mouse   315 AKYCSQECMQQAWDLYHSTECSLGGLLLTLG--VFCHVALRMTLLARFEDVDRVVRMLCDEVGST 377

  Fly   348 -----------KPLDYFLKLKPTIDEELTPEQLISLPK-----------DDFRRVAQLERHQGER 390
                       |..||      |...|...:..|..|.           .::..:..|..|..:.
Mouse   378 DTCLPESKNLVKAFDY------TSQGESEEKSKIGEPPIPGCNVNGKYGSNYNAIFSLLPHTEKH 436

  Fly   391 QPSNFFQHVLMARFLTNCLRAGGYFGSEPKPDEVSII----C-------SLVLRSLQFIQFNTHE 444
            .|.:.|...:....|...|:|........|..::..:    |       :.:||.:..:|.|...
Mouse   437 SPEHRFICAISVSALCRQLKADSVQAQTLKSPKLKAVTPGLCADLTVWGAAMLRHMLQLQCNAQA 501

  Fly   445 VAEL-HKFSSSG---REKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPIN 505
            :..: |..|:..   ..:.|.:...|:|.::|.||||.|.....|.||...:.:.:.|..|..|.
Mouse   502 ITSICHTGSNESIITNSRQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEIL 566

  Fly   506 ENYGPMYTQDERSERQARLKDLYWFECSCDACIDNWPKFDDLPRDVIRFRCDAPNNCSAVI---E 567
            ..|||..::...:|||.||...|:|:|.|.||.....:....|| ...|.|   ..|.|::   :
Mouse   567 HCYGPHESRMGVAERQQRLSSQYFFDCRCGACHAETLRAAAAPR-WEAFCC---KTCRALMQGND 627

  Fly   568 VPPSCNDFMVKCVTCGEITNILKGLKVMQDTEMMTRTAKRLYETGEYPKALAKFVDLIRIMYEVL 632
            |....|:.....|:..::.:.|      ||.:.....|::|..||:..:|:.:.:.........|
Mouse   628 VLSCSNESCTNSVSRDQLVSRL------QDLQQQVCMAQKLLRTGKPEQAIQQLLRCREAAESFL 686

  Fly   633 APPFPDFCESQQHLKDCFLNLGN 655
            :.......|.:..|......|||
Mouse   687 SAEHTVLGEIEDGLAQAHATLGN 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smyd4-3NP_725048.1 TPR repeat 74..103 CDD:276809 6/24 (25%)
TPR repeat 108..142 CDD:276809 15/33 (45%)
TPR repeat 150..177 CDD:276809 6/29 (21%)
SET_SMYD4 235..537 CDD:380934 88/390 (23%)
zf-MYND 284..323 CDD:460312 13/38 (34%)
Smyd4NP_001096081.1 3a0801s09 39..>211 CDD:273380 40/155 (26%)
TPR repeat 68..96 CDD:276809 6/24 (25%)
TPR repeat 101..136 CDD:276809 15/34 (44%)
SET 243..>299 CDD:394802 16/55 (29%)
zf-MYND 296..335 CDD:460312 13/38 (34%)
SET_SMYD4 418..598 CDD:380934 42/179 (23%)
TPR_12 655..725 CDD:315987 11/55 (20%)

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