DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and Smyd5

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001101340.1	Gene:	Smyd5 / 312503	RGDID:	1309153	Length:	417	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	94/388 - (24%)
Similarity:	150/388 - (38%)	Gaps:	109/388 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFV------SVLLEKFAKTHC------ 284
            :|..|||      |.:.:|.|  |:..::.||.:.:|||.|      :.|....|..||
  Rat    23 VEVRFVS------SAKGKGLF--ATQLIRKGETIFIERPLVASQFLWNALYRYRACDHCLRALEK 79

  Fly   285 -------------------ENCFMRTVVPVACPRCADVLYCSEQCREEASKKYHKYEC------- 323
                               |.|.:|..:...|||| .|.|||.:||..|:::||:..|
  Rat    80 AEENAQRLTGKPGQVLPHPELCSVRKDLHQNCPRC-QVTYCSAECRLAAAEQYHQILCPGPSQDD 143

  Fly   324 -----GIVPIIWRS------GASINNHIALRIIA----SKPLDYFLKL-----KPTIDEELTPEQ 368
                 ..:...|||      .|||  .:..|::|    :|..|::::|     ..|.:||   |:
  Rat   144 PRHPLNKLQEAWRSVHYPPETASI--MLMARMVATVKQAKDKDHWVRLFSHFCSKTANEE---EE 203

  Fly   369 LI-SLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGGY-------------FGSEP 419
            :: .|..|.|:...:|.|        ..|...|....|:......|:             .|:..
  Rat   204 IVHKLLGDKFKGQLELLR--------RLFTEALYEETLSQWFTPDGFRSLFALVGTNGQGIGTSS 260

  Fly   420 KPDEVSIICSLVLRSLQFIQFNTHEVAELHK--FSSSGREKSIFI---GGAIYPTLALFNHSCDP 479
            ....|....:|.|:..:..|.:|. :.:|:|  .:::|.    |:   |..::...:..||||.|
  Rat   261 LSQWVHACDALELKPQEREQLDTF-IDQLYKDIEAATGE----FLNCEGSGLFVLQSCCNHSCVP 320

  Fly   480 GVVRYF--RGTTIHINSVRPIEAGLPINENYGPMYTQDERS--ERQARLKDLYWFECSCDACI 538
            .....|  ....:|:.::..||.|..|..:|... .|.|||  .|...|::.|.|.|||..|:
  Rat   321 NAETSFPENNFLLHVTALEDIEPGEEICISYLDC-CQRERSRHSRHKILRENYLFVCSCPKCL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	17/63 (27%)
Smyd5	NP_001101340.1	DUF4599	68..144	CDD:292015	20/76 (26%)
Smyd5	NP_001101340.1	SET	<298..351	CDD:214614	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810