DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and SmydA-8

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001014717.1	Gene:	SmydA-8 / 31200	FlyBaseID:	FBgn0053548	Length:	462	Species:	Drosophila melanogaster

Alignment Length:	441	Identity:	89/441 - (20%)
Similarity:	145/441 - (32%)	Gaps:	132/441 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 IDSNRQEGRFARASADVKPGEELLVERPFVS-VLLEKFAKTHCENC--------FM---RTVVPV 295
            |.|:...||...|:.|:..||.:..||..|: ....|...:.|..|        |:   |..:||
  Fly    59 ISSSTVAGRGVFATRDIAAGELIFQERALVTGPTARKGQLSSCICCHETLPQTGFLCRHRCTLPV 123

  Fly   296 ACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKP-T 359
             |..|:|    ||:         |:.||                           ::|.:.:| .
  Fly   124 -CETCSD----SEE---------HQAEC---------------------------EHFRRWQPKD 147

  Fly   360 ID---EELTPEQLISLPKDDFRRVAQLER--HQGERQPSNFFQHVLMA-------RFLTNCLRAG 412
            :|   |::.|..|         |:....|  |.|:.|     :|::.|       .:....::|.
  Fly   148 VDAEQEQVNPMSL---------RILTAVRVFHLGKEQ-----RHLVDAMQANAERAYRREIIQAA 198

  Fly   413 GYFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSC 477
            ..|.:.|..|.|  ....:.|.:..:..|..|..     ..||..:::..|  ::|..|:.||.|
  Fly   199 QCFRNFPTTDRV--FMDQLFRIVGVLNTNAFEAP-----CRSGGHETLLRG--LFPLTAIMNHEC 254

  Fly   478 DPGVVRYF-RGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDACIDNW 541
            .|....|| .|....:.:.|.|..|..|...|..:...:  ..|...||....|.|.|..|.||
  Fly   255 TPNASHYFENGRLAVVRAARDIPKGGEITTTYTKILWGN--LTRNIFLKMTKHFACDCVRCHDN- 316

  Fly   542 PKFDDLPRDVIRFRCDAPNNCSAVIEVPPSCNDFMV-----------KCVTCGEITNILKGLKVM 595
                          .:.....||:......|...::           :|:||   .|:....|:.
  Fly   317 --------------TENGTYLSALFCREQGCRGLVIPVQTRTLQPDWRCITC---ENVFPHAKMA 364

  Fly   596 QDTEMMTRTAKRLYETGEYPKALAKFVDLIRIMYEVLAPPFPDFCESQQHL 646
            :..:....|......:       ....|:|..:.|:.    |.||.|..::
  Fly   365 KYQDFALNTINNRINS-------CSVQDMIHFINELC----PRFCPSSNYV 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	12/49 (24%)
SmydA-8	NP_001014717.1	SET	<189..293	CDD:214614	25/112 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810