Protein Alignment Smyd4-3 and set-18

DIOPT Version :10

• Sequence 1: NP_725048.1
• Gene: Smyd4-3 / 36234
• FlyBaseID: FBgn0033633
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_871849.1
• Gene: set-18 / 172949
• WormBaseID: WBGene00044070
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 461
• Identity: 108/461 - (23%)
• Similarity: 170/461 - (36%)
• Gaps: 121/461 - (26%)

  Fly   222 IALDQAKPVKLENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCEN 286
            :|:.:.|.|..:.:   |||      |:...:...|.:|     :.|.||.:.:|.......|.|
 Worm     1 MAVKKNKNVPKQED---PLV------QKDEISSIHARIK-----IFETPFATQVLNPKVSEFCAN 51

  Fly   287 CFMRTVVP----VACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIAS 347
            | :|...|    :.|..|...:|||::|:..| ...||.||.      |..||..|
 Worm    52 C-LRGPAPGEKLLRCGGCNFSMYCSKECQATA-WLVHKPECK------RLKASFPN--------- 99

  Fly   348 KPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLERH------QGERQPSNFFQHVL------ 400
            .||...|.|...||                 |:..||::      :.||:.|:...|.:
 Worm   100 LPLTEVLFLSKVID-----------------RIQFLEKNGDKLGIEAERKFSSLVDHKVDIRDDE 147

  Fly   401 --MARFLTNCLRAGGYFGSE--PKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIF 461
              ||.|.....:.|.:.|.|  .|.:...:.|...:        |:|.:     .:::|.|
 Worm   148 EKMAHFEKIFEKMGAFRGEEMIEKGEFFDVFCKATI--------NSHSI-----HTNAGNE---- 195

  Fly   462 IGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENYGPMYTQ--DERSERQARL 524
            :|.|:...::.:||||.|.....|.|..:   .:||:..|:.. ||....:..  |....:..|.
 Worm   196 VGMALDLGVSKYNHSCRPTCSMVFDGYRV---CLRPLVPGVDA-ENTEEAFISYIDVGRSKYIRR 256

  Fly   525 KDL---YWFECSCDACIDNWPKFDDLPRDVIRFRCDAPNNCSAVIEVPPSCNDFMVKCVTCGEIT 586
            :||   ::|.|.|..|:|  |:.|.|    ...||..| .|.|.|....:.....:.|..|..|
 Worm   257 RDLNSRWYFNCECTRCMD--PEDDAL----TAIRCANP-ACDAPILTSETEEPMNIACEKCKTI- 313

  Fly   587 NILKGLKVMQDTEMMTRTAKRLYETGEYPKALAKFVDLIRIMYEVLAPPFPDFCESQQHLKDCFL 651
                   |.:||....:...:.......||..|:...|...:.|:||       :::|     .|
 Worm   314 -------VEEDTVKAAQEYMKTLPASFDPKCPAEIEALPGKLKELLA-------KAEQ-----IL 359

  Fly   652 NLGNVY 657
            :..|||
 Worm   360 HPSNVY 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		SET_SMYD4	235..537	CDD:380934	76/326 (23%)
		zf-MYND	284..323	CDD:460312	14/42 (33%)
set-18	NP_871849.1	zf-MYND	49..90	CDD:460312	14/42 (33%)
		SET	82..274	CDD:394802	56/245 (23%)