back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-3 and SMYD1

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_938015.1	Gene:	SMYD1 / 150572	HGNCID:	20986	Length:	490	Species:	Homo sapiens

Alignment Length:	410	Identity:	89/410 - (21%)
Similarity:	153/410 - (37%)	Gaps:	98/410 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 KLENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPV 295
            ::||      |.:.:...:||..:|:.:....:.:..||.:.:|:.:......|..||.|.....
Human     5 RMEN------VEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQEKLH 63

  Fly   296 ACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTI 360
            .|.:|....||...|:::|... ||.||..:.   |.|...|.:|.|.          .::...:
Human    64 RCGQCKFAHYCDRTCQKDAWLN-HKNECSAIK---RYGKVPNENIRLA----------ARIMWRV 114

  Fly   361 DEE---LTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGGYFGSEPKPD 422
            :.|   ||...|:|:  ||.:               |..:|                ||.|.:.|
Human   115 EREGTGLTEGCLVSV--DDLQ---------------NHVEH----------------FGEEEQKD 146

  Fly   423 -EVSIICSLVL---RSLQF-IQFNTH--EVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPG 480
             .|.:...|..   :|.|| :|:.:|  .|...:.|:.|.:.....:|..|:|.|.|.||.|.|.
Human   147 LRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPN 211

  Fly   481 VVRYFRG-------------TTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFEC 532
            ....|..             ..|.:.::..|..|..:..:|.......|  ||:.:||..|:|:|
Human   212 CTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSE--ERKRQLKKQYYFDC 274

  Fly   533 SCDAC------------IDNWPKFDDLPRDVIRF------RCDAPNNCSAVIEVPPSCNDFMVKC 579
            :|:.|            .||.....::.:::|:|      :.|...:.....||...|.:.:.|.
Human   275 TCEHCQKKLKDDLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQ 339

  Fly   580 VTCGEITNI--LKGLKVMQD 597
            ......|||  |:.|.::.:
Human   340 EPVFADTNIYMLRMLSIVSE 359

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.