DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smyd4-3 and Smyd1

DIOPT Version :10

Sequence 1:NP_725048.1 Gene:Smyd4-3 / 36234 FlyBaseID:FBgn0033633 Length:660 Species:Drosophila melanogaster
Sequence 2:NP_001153599.1 Gene:Smyd1 / 12180 MGIID:104790 Length:490 Species:Mus musculus


Alignment Length:430 Identity:91/430 - (21%)
Similarity:160/430 - (37%) Gaps:107/430 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 LENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPVA 296
            :||      |.:.::..:||..:|:.:....:.:..||.:.:|:.:......|..||.|......
Mouse     6 MEN------VEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDSLINFVCHTCFKRQEKLHR 64

  Fly   297 CPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTID 361
            |.:|....||...|:::|... ||.||..:.   :.|...|.:|.|.          .::...::
Mouse    65 CGQCKFAHYCDRTCQKDAWLN-HKNECAAIK---KYGKVPNENIRLA----------ARIMWRVE 115

  Fly   362 EE---LTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGGYFGSEPKPDE 423
            .|   ||...|:|:  ||.:               |..:|                ||.| :..|
Mouse   116 REGTGLTEGCLVSV--DDLQ---------------NHVEH----------------FGEE-EQKE 146

  Fly   424 VSIICSLVL-----RSLQF-IQFNTH--EVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPG 480
            :.:.....|     :|.|| :|:.:|  .|...:.|:.|.:.....:|..|:|.|.|.||.|.|.
Mouse   147 LRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPN 211

  Fly   481 VVRYFRG-------------TTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFEC 532
            ....|..             ..|.:.::..|..|..:..:|.......|  ||:.:||..|:|:|
Mouse   212 CTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLHLSE--ERRRQLKKQYYFDC 274

  Fly   533 SCDAC-----------IDNWPK-FDDLPRDVIRF------RCDAPNNCSAVIEVPPSCNDFMVKC 579
            ||:.|           ....|| ..::.:::|:|      :.|...:.....||...|.:.:.|.
Mouse   275 SCEHCQKGLKDDLFLAAKEDPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQ 339

  Fly   580 VTCGEITN--ILKGLKV-------MQDTEMMTRTAKRLYE 610
            ......||  :|:.|.:       :|..|..:..|:|:.:
Mouse   340 EPVFADTNLYVLRLLSIASEVLSYLQAYEEASHYARRMVD 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smyd4-3NP_725048.1 TPR repeat 74..103 CDD:276809
TPR repeat 108..142 CDD:276809
TPR repeat 150..177 CDD:276809
SET_SMYD4 235..537 CDD:380934 71/325 (22%)
zf-MYND 284..323 CDD:460312 12/38 (32%)
Smyd1NP_001153599.1 SET_SMYD1 7..281 CDD:380924 74/329 (22%)
zf-MYND 52..90 CDD:460312 12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

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