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Protein Alignment Smyd4-3 and SMYD4

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	651	Identity:	161/651 - (24%)
Similarity:	267/651 - (41%)	Gaps:	131/651 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GKNASLAAEIKERATSAFKAKKWLEAMMLYTRSYVALPSENVAEIRVVLANRSATLYHMQKYQEC 132
            ||::......:|.....|:.|.:..|.:||::. |:....|..::.:..|||||.|:|:.:|:.|
Human    62 GKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKG-VSHSRPNTEDMSLCHANRSAALFHLGQYETC 125

  Fly   133 LIDIKRALDLSYSKDLIYKLYERQARCYMA---LKDYPHTIDSFKKCITAMDDSTLASDKRAKLN 194
            |.||.||....|.:.|..|:..|:|.|.:|   |::...||...::..||.........:..:.|
Human   126 LKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRN 190

  Fly   195 LDAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENE-----------FVSPLVRIDSNRQ 248
            |..:.| ||.:.|..|....|...|   .|:.| .::.|||           .|.||
Human   191 LHRLKM-KMQEKDSLTESFPAALAK---TLEDA-ALREENEQLSNASSSIGLCVDPL-------- 242

  Fly   249 EGRFARASADVKPGEELLVERPFVSVL-----------LEKFAKT-------HCENCFMRTVVPV 295
            :||...|:.|:.|||.|:.|..|||||           |:....|       :|..|...|:..|
Human   243 KGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATV 307

  Fly   296 ACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTI 360
            .|..|:...|||::|.::|.:.||:.||.:..::...|  :..|||||:......:...|:...:
Human   308 PCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLG--VFCHIALRLTLLVGFEDVRKIITKL 370

  Fly   361 DEELT------PE-------------------QLISLP----------KDDFRRVAQLERHQGER 390
            .::::      ||                   .::..|          ::::..|..|..|....
Human   371 CDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENH 435

  Fly   391 QPSNFFQHVLMARFLTNCLRAGG---------YFGSEPK--------PDEVSIICSLVLRSLQFI 438
            .|.:.|...|....|...|.|..         ...|:.|        || |:|....:||.:..:
Human   436 SPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPD-VTIWGVAMLRHMLQL 499

  Fly   439 QFNTHEVAELHKFSSSGR----EKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIE 499
            |.|...:..:......|.    .:.:.:...|:|.::|.||||.|.....|..|...|.:.:.|.
Human   500 QCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIR 564

  Fly   500 AGLPINENYGPMYTQDERSERQARLKDLYWFECSCDAC------IDNWPKFDDLPRDVIRFRCDA 558
            .|..|...|||..::...:|||.:|:..|:|:|:|.||      :...|:::       .|.|
Human   565 KGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWE-------AFCC-- 620

  Fly   559 PNNCSAVIEVPPSCNDFMVKC--VTCGEITNILKGLKV--MQDTEMMTRTAKRLYETGEYPKALA 619
             |:|.|     |...|.:::|  .:|.| :.:.:...|  :||.:...|.|::|...||..:|:.
Human   621 -NSCGA-----PMQGDDVLRCGSRSCAE-SAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQ 678

  Fly   620 K 620
            :
Human   679 R 679

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.