DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsp47F and CD63

DIOPT Version :10

Sequence 1:NP_725044.1 Gene:Tsp47F / 36230 FlyBaseID:FBgn0033629 Length:239 Species:Drosophila melanogaster
Sequence 2:NP_001771.1 Gene:CD63 / 967 HGNCID:1692 Length:238 Species:Homo sapiens


Alignment Length:243 Identity:78/243 - (32%)
Similarity:129/243 - (53%) Gaps:29/243 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GPSLIKYVLFAFNVLFAISGLGILIAGA---VVLADVNEFNHFVEGRVLAP--PIVLIVTGLIIF 64
            |...:|::|:...:.|....:|::..|.   :||:..     .::|.....  |:|:|..|:.:|
Human     6 GMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQT-----IIQGATPGSLLPVVIIAVGVFLF 65

  Fly    65 LIASLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQESIKR--SNS 127
            |:|.:||.||.||:..|:||||:.|::|.:||:|..||..||:..:.....|:.::.::.  .|:
Human    66 LVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNN 130

  Fly   128 EDTMAWDNIQQKLMCCGVDSPADWR---TLSANKTLPGSCCQPQYIDSTVGHC---LESPALGKD 186
            ......|.:|....|||..:..||.   ::|.|: :|.|||    |:.||| |   ....|:.|:
Human   131 HTASILDRMQADFKCCGAANYTDWEKIPSMSKNR-VPDSCC----INVTVG-CGINFNEKAIHKE 189

  Fly   187 KYFQVGCVGKLKDRIEKNAIILIGVGIGIAFIQILGIVLACYLANSIR 234
                 |||.|:...:.||.:::....:||||:::||||.||.|..|||
Human   190 -----GCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIR 232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tsp47FNP_725044.1 Tetraspanin 9..231 CDD:459767 74/234 (32%)
tetraspanin_LEL <134..205 CDD:351888 25/76 (33%)
CD63NP_001771.1 Tetraspanin 10..229 CDD:459767 74/234 (32%)
CD63_LEL 105..203 CDD:239419 29/108 (27%)
Lysosomal targeting motif. /evidence=ECO:0000250|UniProtKB:P41731 234..238
Blue background indicates that the domain is not in the aligned region.

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