Protein Alignment Tsp47F and TSPAN14

DIOPT Version :10

• Sequence 1: NP_725044.1
• Gene: Tsp47F / 36230
• FlyBaseID: FBgn0033629
• Length: 239
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 71/256 - (27%)
• Similarity: 129/256 - (50%)
• Gaps: 32/256 - (12%)

  Fly    10 KYVLFAFNVLFAISGLGILIAG------AVVLADVNEFN--HFVEGRVLAPPIVLIVTGLIIFLI 66
            ||:||::|::|.::|:..|..|      ..||:|:.:..  |.::     |.:::::.|:::|.:
Human    16 KYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGID-----PVVLVLMVGVVMFTL 75

  Fly    67 ASLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQESIK--RSNSED 129
            ...||.||::|:..||..|...:.:||.:||||.:.|.:|:..:....:...:.:||  |.:.:.
Human    76 GFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDL 140

  Fly   130 TMAWDNIQQKLMCCGVDSPADW----------RTLSANKT-LPGSCCQP----QYIDSTVGHCLE 179
            ....|::|:...|||...|.||          .:.|..|. :|.|||.|    :.:::..|:.:.
Human   141 QNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVR 205

  Fly   180 SPALGK--DKYFQVGCVGKLKDRIEKNAIILIGVGIGIAFIQILGIVLACYLANSIRQERA 238
            .....|  :..|..||:..|:..:.:|..|:.||.|.|:.:||.||.||..|.:.|...:|
Human   206 IQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKA 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp47F	NP_725044.1	Tetraspanin	9..231	CDD:459767	69/247 (28%)
		tetraspanin_LEL	<134..205	CDD:351888	21/87 (24%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	68/246 (28%)
		TM4SF9_like_LEL	113..233	CDD:239412	25/119 (21%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		25/117 (21%)