DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsp47F and TSPAN8

DIOPT Version :10

Sequence 1:NP_725044.1 Gene:Tsp47F / 36230 FlyBaseID:FBgn0033629 Length:239 Species:Drosophila melanogaster
Sequence 2:NP_004607.1 Gene:TSPAN8 / 7103 HGNCID:11855 Length:237 Species:Homo sapiens


Alignment Length:248 Identity:82/248 - (33%)
Similarity:120/248 - (48%) Gaps:44/248 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 IKYVLFAFNVLFAISGLGILIAGAVVLADVNEFNHFVEG-------RVLAPPIVLIVTGLIIFLI 66
            |||.:|.||.||.:  .||||....:...|:..:..:.|       ..:|..| ||..|.||.::
Human     8 IKYSMFTFNFLFWL--CGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDI-LIAVGAIIMIL 69

  Fly    67 ASLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQESIK------RS 125
            ..|||.||||||..:|:.|.:.|.:|.::::|.||..:|||...:.:|..:|.|:.|      .|
Human    70 GFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGES 134

  Fly   126 NSEDTMAWDNIQQKLMCCG-VDSPADWRTLSAN--KTLPGSCCQPQYIDSTVGHCLES--PAL-- 183
            ..:...|....|::..||| |:..|||    .|  :..|..|.           ||:.  |..  
Human   135 EKQFQEAIIVFQEEFKCCGLVNGAADW----GNNFQHYPELCA-----------CLDKQRPCQSY 184

  Fly   184 -GKDKYFQVGCVGKLKDRIEKNAIILIGVGIGIAFIQILGI----VLACYLAN 231
             ||..|.:. |:..:||.:.||.||:||:..|:|.|:|||:    ||.|.:.|
Human   185 NGKQVYKET-CISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQIGN 236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tsp47FNP_725044.1 Tetraspanin 9..231 CDD:459767 81/246 (33%)
tetraspanin_LEL <134..205 CDD:351888 21/78 (27%)
TSPAN8NP_004607.1 Tetraspanin 8..232 CDD:459767 80/242 (33%)
hydrophobic region 10..33 10/24 (42%)
hydrophobic region 58..78 10/20 (50%)
hydrophobic region 83..109 7/25 (28%)
TM4SF3_like_LEL 106..206 CDD:239407 30/115 (26%)
hydrophobic region 206..232 12/25 (48%)

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