Protein Alignment Tsp47F and Tspan14

DIOPT Version :10

• Sequence 1: NP_725044.1
• Gene: Tsp47F / 36230
• FlyBaseID: FBgn0033629
• Length: 239
• Species: Drosophila melanogaster
• Sequence 2: NP_666040.1
• Gene: Tspan14 / 52588
• MGIID: 1196325
• Length: 270
• Species: Mus musculus
• Alignment Length: 256
• Identity: 72/256 - (28%)
• Similarity: 131/256 - (51%)
• Gaps: 32/256 - (12%)

  Fly    10 KYVLFAFNVLFAISGLGILIAG------AVVLADVNEFN--HFVEGRVLAPPIVLIVTGLIIFLI 66
            ||:||::|::|.::|:..|..|      ..||:|:.:..  |.::     |.:::::.|:::|.:
Mouse    16 KYLLFSYNIVFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRLHGID-----PVVLVLMVGVVMFTL 75

  Fly    67 ASLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQESIK--RSNSED 129
            ...||.||::|:..||..|...:.:||.:||||.:.|.:|:..:....:...:.:||  |.:.:.
Mouse    76 GFAGCVGALRENICLLKFFCGAIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDL 140

  Fly   130 TMAWDNIQQKLMCCGVDSPADW----------RTLSANKT-LPGSCCQP----QYIDSTVGHCLE 179
            ....|::|:...|||...|.||          .:.|..|. :|.|||.|    :.:::..|:.:.
Mouse   141 QNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVR 205

  Fly   180 SPALGK-DKY-FQVGCVGKLKDRIEKNAIILIGVGIGIAFIQILGIVLACYLANSIRQERA 238
            .....| |:: |..||:..|:..:.:|..|:.||.|.|:.:||.||.||..|.:.|...:|
Mouse   206 IQLKSKWDEFIFTKGCIQALEGWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKA 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp47F	NP_725044.1	Tetraspanin	9..231	CDD:459767	70/247 (28%)
		tetraspanin_LEL	<134..205	CDD:351888	22/87 (25%)
Tspan14	NP_666040.1	Tetraspanin	16..258	CDD:459767	69/246 (28%)
		TM4SF9_like_LEL	113..233	CDD:239412	26/119 (22%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000250|UniProtKB:Q8NG11	114..232		26/117 (22%)