DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsp47F and Cd63

DIOPT Version :9

Sequence 1:	NP_725044.1	Gene:	Tsp47F / 36230	FlyBaseID:	FBgn0033629	Length:	239	Species:	Drosophila melanogaster
Sequence 2:	NP_001036045.1	Gene:	Cd63 / 12512	MGIID:	99529	Length:	238	Species:	Mus musculus

Alignment Length:	241	Identity:	77/241 - (31%)
Similarity:	127/241 - (52%)	Gaps:	25/241 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GPSLIKYVLFAFNVLFAISGLGILIAGAVVLADVNE--FNHFVEGRVLAPPIVLIVTGLIIFLIA 67
            |...:|::|:...:.|....:|::..|..|...:.:  .:....|.:|  |:|:|..|..:||:|
Mouse     6 GMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLL--PVVIIAVGAFLFLVA 68

  Fly    68 SLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQESIK---RSNSED 129
            .:||.||.||:..|:||||:.|::|.:||:||.||..||:..::.....|.|:.::   :.|...
Mouse    69 FVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNKTA 133

  Fly   130 TMAWDNIQQKLMCCGVDSPADWRTL--SANKTLPGSCCQPQYIDSTVGHCLESPALGKD----KY 188
            |:. |.:|::..|||..:..||..:  .|...:|.|||    |:.||| |      |.|    ..
Mouse   134 TIL-DKLQKENNCCGASNYTDWENIPGMAKDRVPDSCC----INITVG-C------GNDFKESTI 186

  Fly   189 FQVGCVGKLKDRIEKNAIILIGVGIGIAFIQILGIVLACYLANSIR 234
            ...|||..:...:.||.:::....:||||:::|||:.:|.|..|||
Mouse   187 HTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIR 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp47F	NP_725044.1	Tetraspannin	9..233	CDD:278750	73/234 (31%)
Tsp47F	NP_725044.1	uroplakin_I_like_LEL	102..205	CDD:239409	30/111 (27%)
Cd63	NP_001036045.1	Tetraspannin	10..227	CDD:395265	72/230 (31%)
		CD63_LEL	105..203	CDD:239419	29/109 (27%)
		Lysosomal targeting motif. /evidence=ECO:0000269\|PubMed:21041449	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850344
Domainoid	1	1.000	128	1.000	Domainoid score	I5295
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4578
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43294
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4418
SonicParanoid	1	1.000	-	-		X3621
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.820