Protein Alignment iotaTry and KLK2

DIOPT Version :10

• Sequence 1: NP_523695.1
• Gene: iotaTry / 36223
• FlyBaseID: FBgn0015001
• Length: 252
• Species: Drosophila melanogaster
• Sequence 2: NP_005542.1
• Gene: KLK2 / 3817
• HGNCID: 6363
• Length: 261
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 87/270 - (32%)
• Similarity: 117/270 - (43%)
• Gaps: 46/270 - (17%)

  Fly    14 LLLGDASDVEATG-------RIIGGSDQLIRNAPWQVSIQISARHECGGVIYSKEIIITAGHCLH 71
            |:|..|..|..||       ||:||.:....:.||||::.......||||:...:.::||.|||.
Human     4 LVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLK 68

  Fly    72 ERSVTLMKVRVGAQNHNY-----GGTLVPVAAYKVHEQFDSRFL-----------HYDIAVLRLS 120
            :.|      :|....||.     .|..|||:....|..::...|           .:|:.:||||
Human    69 KNS------QVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLS 127

  Fly   121 TPLTFGLSTRAINLASTSPSGGTTVTVTGWG--HTDNGALSDSLQKAQLQIIDRGECA---SQKF 180
            .|.......:.:.|.:..|:.|||...:|||  ..:......|||...|.::....||   |:|
Human   128 EPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEK- 191

  Fly   181 GYGADFVGEETICAA--STDADACTGDSGGPLVASSQLVGIVSWGYR-CADDNYPGVYADVAILR 242
                  |.|..:||.  :...|.|.||||||||.:..|.||.|||.. ||....|.||..|...|
Human   192 ------VTEFMLCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYR 250

  Fly   243 PWI--VKAAN 250
            .||  ..|||
Human   251 KWIKDTIAAN 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
iotaTry	NP_523695.1	Tryp_SPc	27..245	CDD:214473	76/241 (32%)
KLK2	NP_005542.1	Tryp_SPc	25..256	CDD:238113	77/243 (32%)