DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment iotaTry and PRSS36

DIOPT Version :9

Sequence 1:	NP_523695.1	Gene:	iotaTry / 36223	FlyBaseID:	FBgn0015001	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	253	Identity:	80/253 - (31%)
Similarity:	111/253 - (43%)	Gaps:	28/253 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DASDVEATGRIIGGSDQLIRNAPWQVSIQISARHECGGVIYSKEIIITAGHCLHERSVTL----- 77
            |....|.:.||:|||:......|||||:.....|.|||.:.:...:::|.||..... ||
Human    37 DCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNG-TLEPAAE 100

  Fly    78 MKVRVGAQNHNYGGTL-----VPVAAYKVHEQFDSRFLHYDIAVLRLSTPLTFGLSTRAINL--A 135
            ..|.:|.  |:..|.|     ..|||..|...:....|..|:|:|||::|.:.|.:...:.|  |
Human   101 WSVLLGV--HSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRA 163

  Fly   136 STSPSGGTTVTVTGWG---HTDNGALSDSLQKAQLQIIDRGECA---SQKFGYGADF-VGEETIC 193
            |.....||....||||   ..|...|...||:.:|:::....|.   ||...:.... :....:|
Human   164 SHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLC 228

  Fly   194 AASTDA--DACTGDSGGPLVASSQ----LVGIVSWGYRCADDNYPGVYADVAILRPWI 245
            |...:.  |.|.||||||||....    ..||.|:|:.|...|.|||:..||....||
Human   229 AGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iotaTry	NP_523695.1	Tryp_SPc	27..245	CDD:214473	76/242 (31%)
iotaTry	NP_523695.1	Tryp_SPc	28..247	CDD:238113	77/243 (32%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	76/242 (31%)
		Tryp_SPc	47..289	CDD:238113	77/243 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030