DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and PRSS12

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_003610.2	Gene:	PRSS12 / 8492	HGNCID:	9477	Length:	875	Species:	Homo sapiens

Alignment Length:	276	Identity:	82/276 - (29%)
Similarity:	120/276 - (43%)	Gaps:	51/276 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSAVACALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHS-----CGGSIYSSNVIV 67
            ||:| |.|      .||.:...||:||..:....:|||:||:...||.     ||.::.||..::
Human   615 LSSV-CGL------RLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVL 672

  Fly    68 TAAHCLQSVSASV--LQIRAGSSYWSSGGVTFSVSSFKN---------HEGYNANTMVNDIAIIK 121
            |||||.:....|.  ..:|.|..:      |.....|:.         |..|..:....|||:::
Human   673 TAAHCFKRYGNSTRSYAVRVGDYH------TLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVR 731

  Fly   122 ING----ALTFSSTI--KAIGLASSNPANGAA-ASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQ 179
            :.|    ...|||.:  ..:.|....|...|: ..::|||......|   ..||...:.::.:..
Human   732 LQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYS---RTLQQAAIPLLPKRF 793

  Fly   180 CASSTYGYGSQIRSTMICAAASGK----DACQGDSGGPLV-----SGGVLVGVVSWGYGCAYSNY 235
            |...   |..:....|:||....:    |:|||||||||:     ...|:.||.||||||...:.
Human   794 CEER---YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDS 855

  Fly   236 PGVYADVAALRSWVIS 251
            ||||..|:|...|:.|
Human   856 PGVYTKVSAFVPWIKS 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	73/250 (29%)
PRSS12	NP_003610.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..88
		KR	99..164	CDD:214527
		SR	170..270	CDD:214555
		SRCR	175..270	CDD:278931
		SR	280..380	CDD:214555
		SRCR	285..380	CDD:278931
		SR	387..486	CDD:214555
		SRCR	392..485	CDD:278931
		SR	500..599	CDD:214555
		SRCR	510..599	CDD:278931
		Zymogen activation region	619..630		4/16 (25%)
		Tryp_SPc	630..869	CDD:214473	73/250 (29%)
		Tryp_SPc	631..872	CDD:238113	74/253 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910