DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and Tmprss6

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	257	Identity:	91/257 - (35%)
Similarity:	132/257 - (51%)	Gaps:	38/257 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQS-- 75
            |.|.|         |..|||||:.::...:|||.|||..|.|.|||::.:...::|||||.|.
Mouse   568 CGLQG---------LSSRIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDS 623

  Fly    76 -VSASVLQIRAG----SSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKINGALTFSSTIKAI 135
             .|..:..:..|    :|.| .|.|:|.||....|..:..::...|:|:::::..:.:|:|::.:
Mouse   624 MASPKLWTVFLGKMRQNSRW-PGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPV 687

  Fly   136 GLASSNPAN------GAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRST 194
            .|    ||.      |....::|||....| ..:.:.||.|:|.:|.|..| |..|.|  |:...
Mouse   688 CL----PARSHFFEPGQHCWITGWGAQREG-GPVSNTLQKVDVQLVPQDLC-SEAYRY--QVSPR 744

  Fly   195 MICAA--ASGKDACQGDSGGPLV----SG-GVLVGVVSWGYGCAYSNYPGVYADVAALRSWV 249
            |:||.  ...|||||||||||||    || ..|.|:||||.||...|:.|||..|..:.:|:
Mouse   745 MLCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	86/238 (36%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	86/238 (36%)
		Tryp_SPc	577..809	CDD:238113	86/239 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910