DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and C1S

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001725.1	Gene:	C1S / 716	HGNCID:	1247	Length:	688	Species:	Homo sapiens

Alignment Length:	286	Identity:	72/286 - (25%)
Similarity:	112/286 - (39%)	Gaps:	60/286 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CALGGT-VPEGLLPQL----------------DGRIVGGSATTISSFPWQISLQRSGSHSCGGSI 60
            ||..|: |.|.|.|:|                ..||:|||...|.:||||:......:   ||::
Human   403 CAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWA---GGAL 464

  Fly    61 YSSNVIVTAAHCLQS--------VSASVLQIRAGSSYWSSGGVTFSVSSFKNHEGYNANT-MVND 116
            .:...::||||.::.        .|.||...|...|...:....|....:|..|.....| ..||
Human   465 INEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDND 529

  Fly   117 IAIIKINGALTFSSTIKAIGLASS----NPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQ 177
            ||::::...:....|:..|.|..:    |..:|....:||||.......::  :|:...:.:...
Human   530 IALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAV--RLKAARLPVAPL 592

  Fly   178 SQCA----------SSTYGYGSQIRSTMICAAA-SGKDACQGDSGGPLV-------SGGVLVGVV 224
            .:|.          :..|.:    ...||||.. .|.|:|:|||||...       :.....|:|
Human   593 RKCKEVKVEKPTADAEAYVF----TPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLV 653

  Fly   225 SWGYGCAYSNYPGVYADVAALRSWVI 250
            |||..|  ..| |:|..|.....|::
Human   654 SWGPQC--GTY-GLYTRVKNYVDWIM 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	63/249 (25%)
C1S	NP_001725.1	CUB	18..129	CDD:238001
		FXa_inhibition	143..171	CDD:405372
		CUB	175..287	CDD:395345
		CCP	294..355	CDD:153056
		Sushi	359..421	CDD:395037	8/17 (47%)
		Tryp_SPc	438..678	CDD:238113	63/251 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910