DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	267	Identity:	92/267 - (34%)
Similarity:	130/267 - (48%)	Gaps:	36/267 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KFVILLSAVACALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIV 67
            |.|:.|..:||.:      .|......|||||.:....::|||:||.....|.|||||.:...||
Human   271 KAVVSLRCIACGV------NLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIV 329

  Fly    68 TAAHCLQ---------SVSASVLQIRAGSSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKIN 123
            |||||::         :..|.:|  |....::.:|   :.|....:|..|::.|..||||::|:.
Human   330 TAAHCVEKPLNNPWHWTAFAGIL--RQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKLQ 389

  Fly   124 GALTFSSTIKAIGLASSNPANGAAAS----VSGWG-TLSYGSSSIPSQLQYVNVNIVSQSQCASS 183
            ..|||:..:|.:.|  .||.......    :|||| |...|.:|  ..|....|.::...:| :|
Human   390 KPLTFNDLVKPVCL--PNPGMMLQPEQLCWISGWGATEEKGKTS--EVLNAAKVLLIETQRC-NS 449

  Fly   184 TYGYGSQIRSTMICAA--ASGKDACQGDSGGPLVSG----GVLVGVVSWGYGCAYSNYPGVYADV 242
            .|.|.:.|...||||.  ....|:||||||||||:.    ..|:|..|||.|||.:..||||.:|
Human   450 RYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNV 514

  Fly   243 AALRSWV 249
            .....|:
Human   515 MVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	85/238 (36%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133	5/11 (45%)
		Tryp_SPc	292..521	CDD:214473	85/238 (36%)
		Tryp_SPc	293..524	CDD:238113	85/239 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910