DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and tmprss2

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	291	Identity:	109/291 - (37%)
Similarity:	145/291 - (49%)	Gaps:	60/291 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSAVACALGG-----TVPEGLL-PQLD-----------------------GRIVGGSATTISS-- 41
            |:..|||..|     :..:|:| |.||                       .|||||  ||::|
Zfish   200 LAKQACAEIGYKDTYSGYQGILSPSLDFISACQSSTAVSLKCTDCGRSTGNRIVGG--TTVTSKG 262

  Fly    42 -FPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQSVS-ASVLQIRAG----SSYWSSGGVTFSVS 100
             :|||:||..||.|.|||||.:...|:|||||:...| .....:.||    |...|:.|  .||:
Zfish   263 VWPWQVSLHYSGRHLCGGSIITPYWILTAAHCVHQFSNPGGWTVYAGYLTQSEMASASG--NSVN 325

  Fly   101 SFKNHEGYNANTMVNDIAIIKINGALTFSSTIKAIGLASSNPANGAAAS------VSGWGTLSYG 159
            ....|: :|.||..||||::::|.|||.|:.|:.:.|    |..|.:.:      |:|||.|..|
Zfish   326 RIVIHD-FNPNTNENDIALMRLNTALTISTNIRPVCL----PNKGMSFTAQQDCYVTGWGALFSG 385

  Fly   160 SSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAA--ASGKDACQGDSGGPLVSG----G 218
            .|| .:.||...:.::..:.|.|... |...|..|||||.  |.|.|:||||||||||:.    .
Zfish   386 GSS-SATLQEAKIQLIDSTICNSRPV-YNGLITDTMICAGKLAGGVDSCQGDSGGPLVTNVRSLW 448

  Fly   219 VLVGVVSWGYGCAYSNYPGVYADVAALRSWV 249
            .|:|..|||.|||..|.||||.:|.....|:
Zfish   449 WLLGDTSWGDGCAVRNKPGVYGNVTYFLDWI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	98/238 (41%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060
		SRCR_2	173..248	CDD:295335	10/47 (21%)
		Tryp_SPc	251..479	CDD:214473	98/238 (41%)
		Tryp_SPc	252..482	CDD:238113	98/239 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910