DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and LPA

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_005568.2	Gene:	LPA / 4018	HGNCID:	6667	Length:	2040	Species:	Homo sapiens

Alignment Length:	259	Identity:	81/259 - (31%)
Similarity:	116/259 - (44%)	Gaps:	68/259 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PQLD-----GRIVGGSATTISSFPWQISLQ-RSGSHSCGGSIYSSNVIVTAAHCLQSVSASVLQI 83
            ||::     |.||||......|:|||:||: |.|.|.|||::.|...::||||||:..|..
Human  1809 PQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRP---- 1869

  Fly    84 RAGSSYWSSGGVTFSVSSFK----NHEGYNANTMVN--------------DIAIIKINGALTFSS 130
                            ||:|    .|:..|..:.|.              |||::|::.....:.
Human  1870 ----------------SSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITD 1918

  Fly   131 TIKAIGLASSNPANGAAAS--VSGWGTL--SYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQI 191
            .:....|.|.:....|...  ::|||..  ::|:    ..|:...:.::....|  :.|.|
Human  1919 KVMPACLPSPDYMVTARTECYITGWGETQGTFGT----GLLKEAQLLVIENEVC--NHYKY---- 1973

  Fly   192 RSTMICA--AASGKDACQGDSGGPLV----SGGVLVGVVSWGYGCAYSNYPGVYADVAALRSWV 249
                |||  .|.|.|:||||||||||    ...:|.||.|||.|||..|.|||||.|:...:|:
Human  1974 ----ICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWI 2033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	77/247 (31%)
LPA	NP_005568.2	Kringle	28..105	CDD:278480
		Kringle	142..219	CDD:278480
		Kringle	256..333	CDD:278480
		Kringle	370..447	CDD:278480
		Kringle	484..561	CDD:278480
		Kringle	598..675	CDD:278480
		Kringle	712..789	CDD:278480
		Kringle	826..903	CDD:278480
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:278480
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		KR	1386..1466	CDD:214527
		KR	1500..1581	CDD:214527
		KR	1614..1695	CDD:214527
		Kringle	1720..1799	CDD:278480
		Tryp_SPc	1820..2034	CDD:238113	78/248 (31%)
		Tryp_SPc	1820..2033	CDD:214473	77/246 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910