DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and TMPRSS11F

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_997290.2	Gene:	TMPRSS11F / 389208	HGNCID:	29994	Length:	438	Species:	Homo sapiens

Alignment Length:	249	Identity:	82/249 - (32%)
Similarity:	119/249 - (47%)	Gaps:	46/249 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RIVGGSATTI-SSFPWQISLQRSGS-HSCGGSIYSSNVIVTAAHCLQSVSASVLQIRAGSSYWSS 92
            |||.|..|.: ..:|||.|||..|| |.||.|:.|:..::|||||                :|.:
Human   205 RIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHC----------------FWKN 253

  Fly    93 GGVTFSVSSF----------KN------HEGYNANTMVNDIAIIKINGALTFSSTIKAIGLASSN 141
            ...|..:::|          :|      ||.|:..|..||||:::::..:.||:.::.:.|..|:
Human   254 KDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSS 318

  Fly   142 ---PANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAA-ASG 202
               |.. .:..|:|:|:: .....|.:.|:...|..:|...|..... |...|...|:||. ..|
Human   319 IKLPPK-TSVFVTGFGSI-VDDGPIQNTLRQARVETISTDVCNRKDV-YDGLITPGMLCAGFMEG 380

  Fly   203 K-DACQGDSGGPLVSGG----VLVGVVSWGYGCAYSNYPGVYADVAALRSWVIS 251
            | |||:||||||||...    .:||:||||..||....||||..|...|.|:.|
Human   381 KIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIAS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	80/245 (33%)
TMPRSS11F	NP_997290.2	SEA	59..154	CDD:279699
		Tryp_SPc	205..432	CDD:214473	80/245 (33%)
		Tryp_SPc	206..435	CDD:238113	81/248 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910