DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and KLKB1

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	240	Identity:	87/240 - (36%)
Similarity:	122/240 - (50%)	Gaps:	26/240 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RIVGGSATTISSFPWQISLQ---RSGSHSCGGSIYSSNVIVTAAHCLQSVS-ASVLQIRAGSSYW 90
            |||||:.::...:|||:|||   .:..|.||||:.....::|||||...:. ..|.:|.:|....
Human   401 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNL 465

  Fly    91 SSGGVTFSVSSFKN---HEGYNANTMVNDIAIIKINGALTFSSTIKAIGLASSNPANGAAAS--- 149
            |........|..|.   |:.|..:...:|||:||:...|.::...|.|.|    |:.|..::
Human   466 SDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICL----PSKGDTSTIYT 526

  Fly   150 ---VSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAA--ASGKDACQGD 209
               |:||| .|.....|.:.||.||:.:|:..:|......|  :|...|:||.  ..|||||:||
Human   527 NCWVTGWG-FSKEKGEIQNILQKVNIPLVTNEECQKRYQDY--KITQRMVCAGYKEGGKDACKGD 588

  Fly   210 SGGPLV--SGGV--LVGVVSWGYGCAYSNYPGVYADVAALRSWVI 250
            ||||||  ..|:  |||:.|||.|||....||||..||....|::
Human   589 SGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWIL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	86/237 (36%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	86/237 (36%)
		Tryp_SPc	402..632	CDD:238113	85/236 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910