DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and HPN

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001362370.1	Gene:	HPN / 3249	HGNCID:	5155	Length:	417	Species:	Homo sapiens

Alignment Length:	242	Identity:	90/242 - (37%)
Similarity:	131/242 - (54%)	Gaps:	25/242 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCL--QSVSASVLQIRAGS-SYWS 91
            |||||..|::..:|||:||:..|:|.||||:.|.:.::|||||.  ::...|..::.||: :..|
Human   162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226

  Fly    92 SGGVTFSVSSFKNHEGY------NANTMVNDIAIIKINGALTFSSTIKAIGLASSNPA--NGAAA 148
            ..|:...|.:...|.||      |:....||||::.::..|..:..|:.:.|.::..|  :|...
Human   227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKIC 291

  Fly   149 SVSGWG-TLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAA--ASGKDACQGDS 210
            :|:||| |..||..:  ..||...|.|:|...|..:.: ||:||:..|.||.  ..|.|||||||
Human   292 TVTGWGNTQYYGQQA--GVLQEARVPIISNDVCNGADF-YGNQIKPKMFCAGYPEGGIDACQGDS 353

  Fly   211 GGPLVSGGV--------LVGVVSWGYGCAYSNYPGVYADVAALRSWV 249
            |||.|....        |.|:||||.|||.:..||||..|:..|.|:
Human   354 GGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	89/240 (37%)
HPN	NP_001362370.1	Hepsin-SRCR	51..159	CDD:401275
HPN	NP_001362370.1	Tryp_SPc	163..400	CDD:238113	88/239 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910