DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and Tmprss6

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	257	Identity:	89/257 - (34%)
Similarity:	130/257 - (50%)	Gaps:	38/257 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQS-- 75
            |.|.|.         ..|||||:.::...:|||.|||..|.|.|||::.:...::|||||.|.
  Rat   568 CGLQGP---------SSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDS 623

  Fly    76 -VSASVLQIRAG----SSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKINGALTFSSTIKAI 135
             .|..:..:..|    :|.| .|.|:|.||....|..:..::...|:|:::::..:.:|:|::.:
  Rat   624 MASPRLWTVFLGKMRQNSRW-PGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPV 687

  Fly   136 GLASSNPAN------GAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRST 194
            .|    ||.      |....::|||....|... .|.||.|:|.::.|..| :..|.|  |:...
  Rat   688 CL----PARSHFFEPGQHCWITGWGAQREGGPG-SSTLQKVDVQLIPQDLC-NEAYRY--QVTPR 744

  Fly   195 MICAA--ASGKDACQGDSGGPLV----SG-GVLVGVVSWGYGCAYSNYPGVYADVAALRSWV 249
            |:||.  ...|||||||||||||    || ..|.|:||||.||...|:.|||..|..:.:|:
  Rat   745 MLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	85/238 (36%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	85/238 (36%)
		Tryp_SPc	577..809	CDD:238113	85/239 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910