DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and HABP2

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_004123.1	Gene:	HABP2 / 3026	HGNCID:	4798	Length:	560	Species:	Homo sapiens

Alignment Length:	268	Identity:	84/268 - (31%)
Similarity:	115/268 - (42%)	Gaps:	42/268 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TVPEGLLPQLDG------------RIVGGSATTISSFPWQISLQRS--------GSHSCGGSIYS 62
            |.|...||..|.            ||.||..:|....|||.|||.|        ..|.|||::..
Human   289 TEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIH 353

  Fly    63 SNVIVTAAHCLQSVSASVLQIRAGSSYWSSGGV---TFSVSSFKNHEGYNANTMV--NDIAIIK- 121
            ...::||||| ..:....|::..|.........   :|.|.....:..||....:  ||||::|
Human   354 PCWVLTAAHC-TDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKL 417

  Fly   122 --INGALTFSST-IKAIGLASSNPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASS 183
              ::|.....|. :|.:.|...:..:|:...:||||....|..|  .||....|.:::.:.| :|
Human   418 KPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGS--RQLLDAKVKLIANTLC-NS 479

  Fly   184 TYGYGSQIRSTMICAA---ASGKDACQGDSGGPLV---SGGVLV-GVVSWGYGCAYSNYPGVYAD 241
            ...|...|..:||||.   ..|:|.|||||||||.   .|...| |:||||..|  ...||||..
Human   480 RQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLEC--GKRPGVYTQ 542

  Fly   242 VAALRSWV 249
            |....:|:
Human   543 VTKFLNWI 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	78/242 (32%)
HABP2	NP_004123.1	EGF	77..106	CDD:306513
		KR	191..277	CDD:238056
		Tryp_SPc	314..553	CDD:238113	78/243 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910