DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaTry and tmprss6

DIOPT Version :9

Sequence 1:	NP_725034.1	Gene:	gammaTry / 36221	FlyBaseID:	FBgn0010359	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	245	Identity:	86/245 - (35%)
Similarity:	123/245 - (50%)	Gaps:	34/245 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQSVSASVLQIRAGSSYWS--S 92
            |:|||:......:|||.|||..|.|.|||::.:...|:|||||....|      .|....|:  .
Frog   570 RLVGGTQAQEGEWPWQASLQVRGEHICGGTLVADQWILTAAHCFTPES------YASPEVWTVYL 628

  Fly    93 GGVTFSVSSFKN----------HEGYNANTMVNDIAIIKINGALTFSST-IKAIGLASSNP--AN 144
            |.|..|.|:.|.          |..|:.::...|:|::.::..:..:|. ::.|.|.||..  ..
Frog   629 GKVRLSRSTQKELAFKVIRLVIHPFYDEDSHDYDVALVLLDHLVPLTSPHVQPICLPSSTHHFPT 693

  Fly   145 GAAASVSGWGTL-SYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAA--ASGKDAC 206
            |::..|:|||:: ..|.:|  ..||.|::.:|:|..| :..|.|  ||...|:||.  ...||||
Frog   694 GSSCWVTGWGSVKENGPTS--DVLQKVDIQLVAQDIC-TELYRY--QISPRMLCAGYRDGSKDAC 753

  Fly   207 QGDSGGPLV----SG-GVLVGVVSWGYGCAYSNYPGVYADVAALRSWVIS 251
            |||||.|||    || ....|:||||.||....|.|||:.:..|..|:.|
Frog   754 QGDSGSPLVCKTASGRWFQAGLVSWGAGCGIPRYFGVYSRITRLVQWIES 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaTry	NP_725034.1	Tryp_SPc	30..249	CDD:214473	84/241 (35%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	85/243 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910