DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment thetaTry and PRSS1

DIOPT Version :9

Sequence 1:	NP_523693.1	Gene:	thetaTry / 36218	FlyBaseID:	FBgn0011555	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	263	Identity:	96/263 - (36%)
Similarity:	130/263 - (49%)	Gaps:	37/263 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLVCLAVGSACAGTVGVSNGDPFEREGRIVGGEDTTIGAHPYQVSLQTKSGSHFCGGSLINEDTV 71
            ||:...|.:|.|.        ||:.:.:||||.:....:.||||||  .||.||||||||||..|
Human   229 LLILTFVAAALAA--------PFDDDDKIVGGYNCEENSVPYQVSL--NSGYHFCGGSLINEQWV 283

  Fly    72 VTAAHCLVGRKVSKVFVRLGSTLYN----EGG-IVVAVRELAYNEDYNSKTMEYDVGILKLDEKV 131
            |:|.||.    .|::.||||.  :|    ||. ..:...::..:..|:.||:..|:.::||..:.
Human   284 VSAGHCY----KSRIQVRLGE--HNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRA 342

  Fly   132 KETENIRYIELATETPPTGTTAVVTGWGSKC-----YFWCMTLPKTLQEVYVNIVDWKTCASDEY 191
            .....:..|.|.|..|.|||..:::|||:..     |      |..||.:...::....|   |.
Human   343 VINARVSTISLPTAPPATGTKCLISGWGNTASSGADY------PDELQCLDAPVLSQAKC---EA 398

  Fly   192 KYGEIIYDSMVCA--YEKKKDACQGDSGGPLAVGNTLVGIVSWGYACASNLLPGVYSDVPALRKW 254
            .|...|..:|.|.  .|..||:||||||||:.....|.|:||||..||....||||:.|....||
Human   399 SYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKW 463

  Fly   255 ILN 257
            |.|
Human   464 IKN 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thetaTry	NP_523693.1	Tryp_SPc	34..255	CDD:214473	86/232 (37%)
thetaTry	NP_523693.1	Tryp_SPc	35..255	CDD:238113	86/231 (37%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	86/232 (37%)
		Tryp_SPc	249..467	CDD:238113	89/235 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820