Protein Alignment thetaTry and KLK12

DIOPT Version :10

• Sequence 1: NP_523693.1
• Gene: thetaTry / 36218
• FlyBaseID: FBgn0011555
• Length: 262
• Species: Drosophila melanogaster
• Sequence 2: NP_062544.1
• Gene: KLK12 / 43849
• HGNCID: 6360
• Length: 254
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 82/256 - (32%)
• Similarity: 123/256 - (48%)
• Gaps: 42/256 - (16%)

  Fly     5 VVLLVCLAVGSACAGTVGVSNGDPFEREGRIVGGEDTTIGAHPYQVSLQTKSGSHFCGGSLINED 69
            :.||:|: :|.:.|.|..:.||....|            .:.|:||.| .:..|..|||.||:..
Human     5 IFLLLCV-LGLSQAATPKIFNGTECGR------------NSQPWQVGL-FEGTSLRCGGVLIDHR 55

  Fly    70 TVVTAAHCLVGRKVSKVFVRLGSTLYNEGGIVVAVRELAYNEDY-----NSKTMEYDVGILKLDE 129
            .|:|||||    ..|:.:||||....::......:|...::..:     .|.:.|:|:.:|:|..
Human    56 WVLTAAHC----SGSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRL 116

  Fly   130 KVKETENIRYIELATETPPTGTTAVVTGWGSKCYFWCMT------LPKTLQEVYVNIVDWKTCAS 188
            .|:.|.:::.:.|..:....||...|:|||       :|      .|..||.:.::||...||..
Human   117 PVRVTSSVQPLPLPNDCATAGTECHVSGWG-------ITNHPRNPFPDLLQCLNLSIVSHATCHG 174

  Fly   189 DEYKYGEIIYDSMVCA-YEKKKDACQGDSGGPLAVGNTLVGIVSWGYA--CASNLLPGVYS 246
               .|...|..:|||| ....:|||||||||||..|..|.|:||||..  |..:.:||||:
Human   175 ---VYPGRITSNMVCAGGVPGQDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYT 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thetaTry	NP_523693.1	Tryp_SPc	34..255	CDD:214473	73/227 (32%)
KLK12	NP_062544.1	Tryp_SPc	22..236	CDD:238113	76/238 (32%)