Protein Alignment thetaTry and KLK1

DIOPT Version :10

• Sequence 1: NP_523693.1
• Gene: thetaTry / 36218
• FlyBaseID: FBgn0011555
• Length: 262
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 91/285 - (31%)
• Similarity: 129/285 - (45%)
• Gaps: 70/285 - (24%)

  Fly     7 LLVCLAVGSACAGTVGVSNGDPFEREGRIVGGEDTTIGAHPYQVSLQTKSGSHF----CGGSLIN 67
            |::|||:...     |.....|.  :.|||||.:....:.|:|.:|.     ||    |||.|::
Human     4 LVLCLALSLG-----GTGAAPPI--QSRIVGGWECEQHSQPWQAALY-----HFSTFQCGGILVH 56

  Fly    68 EDTVVTAAHCL-------VGR-------------KVSKVFVRLG---STLYNEGGIVVAVRELAY 109
            ...|:|||||:       :||             .||:.|...|   |.|.|.      .|:.
Human    57 RQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENH------TRQA-- 113

  Fly   110 NEDYNSKTMEYDVGILKLDEKVKE-TENIRYIELATETPPTGTTAVVTGWGS---KCYFWCMTLP 170
            :|||:     :|:.:|:|.|.... |:.::.:||.||.|..|:|.:.:||||   :.:    :.|
Human   114 DEDYS-----HDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENF----SFP 169

  Fly   171 KTLQEVYVNIVDWKTCASDEYKYGEI--IYDSMVCA--YEKKKDACQGDSGGPLAVGNTLVGIVS 231
            ..||     .||.|...:||.|...:  :.|.|:|.  .|..||.|.|||||||.....|.|:.|
Human   170 DDLQ-----CVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTS 229

  Fly   232 WGYA-CASNLLPGVYSDVPALRKWI 255
            |||. |.:...|.|...|.:..|||
Human   230 WGYVPCGTPNKPSVAVRVLSYVKWI 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thetaTry	NP_523693.1	Tryp_SPc	34..255	CDD:214473	83/256 (32%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	84/257 (33%)