Protein Alignment thetaTry and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_523693.1
• Gene: thetaTry / 36218
• FlyBaseID: FBgn0011555
• Length: 262
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 75/264 - (28%)
• Similarity: 120/264 - (45%)
• Gaps: 29/264 - (10%)

  Fly    14 GSACAGTVGVSNGDPFEREGRIVGGEDTTIGAHPYQVSLQTKSGS---HFCGGSLINEDTVVTAA 75
            |.|.|...|.:......:..||:||.:...||.|:.||||.|.|.   |.|||:|:.|..|:|||
Human    57 GGAHAEDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAA 121

  Fly    76 HCLVGRKVSKVFVRLGSTLYNEGGI----VVAVRELAYNEDYNSKTMEYDVGILKLDEKVKETEN 136
            ||........::..:..|....|..    .:.::.:..:.::..::...|:.:..|.:.|:..:.
Human   122 HCTKDASDPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDY 186

  Fly   137 IRYIELATETPPTGTTAVVTGWGSKCYF--WCMT-----LPKTLQEVYVNIVDWKTCASDEYKYG 194
            |:.|.|     |.....::.| .:||:.  |..|     ....||:..|:.:..:.|.| |..||
Human   187 IQPICL-----PFDVFQILDG-NTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNS-ERSYG 244

  Fly   195 EIIYDSMVCAYEKKK--DACQGDSGGPLAV------GNTLVGIVSWGYACASNLLPGVYSDVPAL 251
            .||.::..||.::..  |.|:|||||||..      ...::||.|:|:.|.....||||......
Human   245 GIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFY 309

  Fly   252 RKWI 255
            :||:
Human   310 QKWL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thetaTry	NP_523693.1	Tryp_SPc	34..255	CDD:214473	70/242 (29%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46
		Tryp_SPc	78..316	CDD:238113	70/243 (29%)