DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment etaTry and KLKB1

DIOPT Version :9

Sequence 1:	NP_523692.1	Gene:	etaTry / 36217	FlyBaseID:	FBgn0011554	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	255	Identity:	85/255 - (33%)
Similarity:	135/255 - (52%)	Gaps:	26/255 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SAQSDGRIVGGADTSSYYTKYVVQLRRRSSSSSSYAQTCGGCILDAVTIATAAHCVYNREAENFL 85
            :.::..|||||.::|.....:.|.|:.:.::.   ...|||.::....:.|||||......::..
Human   395 TTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQ---RHLCGGSLIGHQWVLTAAHCFDGLPLQDVW 456

  Fly    86 VVAGDDSRGGMNGVV-----------VRVSKLIPHELYNSSTMDNDIALVVVDPPLPLDSFSTME 139
            .:        .:|::           .::.::|.|:.|..|..::||||:.:..||....|....
Human   457 RI--------YSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPI 513

  Fly   140 AIEIASEQPAVGVQATISGWGYTKENGLSSDQLQQVKVPIVDSEKCQEAYYWRPISEGMLCAGLS 204
            .:....:...:.....::|||::||.|...:.||:|.:|:|.:|:||:.|....|::.|:|||..
Human   514 CLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYK 578

  Fly   205 EGGKDACQGDSGGPLVVAN----KLAGIVSWGEGCARPNYPGVYANVAYYKDWIAKQRTS 260
            |||||||:||||||||..:    :|.||.||||||||...||||..||.|.|||.::..|
Human   579 EGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQS 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
etaTry	NP_523692.1	Tryp_SPc	27..254	CDD:214473	82/241 (34%)
etaTry	NP_523692.1	Tryp_SPc	28..257	CDD:238113	83/243 (34%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	82/241 (34%)
		Tryp_SPc	402..632	CDD:238113	81/240 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910