DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment etaTry and F12

DIOPT Version :9

Sequence 1:	NP_523692.1	Gene:	etaTry / 36217	FlyBaseID:	FBgn0011554	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	268	Identity:	88/268 - (32%)
Similarity:	125/268 - (46%)	Gaps:	46/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SAQSDGRIVGGADTSSYYTKYVVQLRRRSSSSSSYAQTCGGCILDAVTIATAAHCVYNREA-ENF 84
            |..|..|:|||.........|:..|....|       .|.|.::....:.|||||:.:|.| |:.
Human   366 SLSSMTRVVGGLVALRGAHPYIAALYWGHS-------FCAGSLIAPCWVLTAAHCLQDRPAPEDL 423

  Fly    85 LVVAGDDSRG----GMNGVVVRVSKLIPHELYNSSTMDNDIALV-----------VVDP---PLP 131
            .||.|.:.|.    ....:.||..:|  ||.::..:..:|:||:           ::.|   |:.
Human   424 TVVLGQERRNHSCEPCQTLAVRSYRL--HEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVC 486

  Fly   132 LDSFSTMEAIEIASEQPAVGVQATISGWGYTKENGLS-SDQLQQVKVPIVDSEKCQEA-YYWRPI 194
            |.|         .:.:|:......::|||:..|.... :..||:.:||.:..|:|... .:...|
Human   487 LPS---------GAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSI 542

  Fly   195 SEGMLCAGLSEGGKDACQGDSGGPLVVANK-------LAGIVSWGEGCARPNYPGVYANVAYYKD 252
            ..||||||..|||.||||||||||||..::       |.||:|||.||...|.||||.:||||..
Human   543 LPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLA 607

  Fly   253 WIAKQRTS 260
            ||.:...|
Human   608 WIREHTVS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
etaTry	NP_523692.1	Tryp_SPc	27..254	CDD:214473	83/254 (33%)
etaTry	NP_523692.1	Tryp_SPc	28..257	CDD:238113	84/256 (33%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359
		Tryp_SPc	372..609	CDD:214473	83/254 (33%)
		Tryp_SPc	373..612	CDD:238113	84/256 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910