DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment etaTry and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_523692.1	Gene:	etaTry / 36217	FlyBaseID:	FBgn0011554	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	217	Identity:	69/217 - (31%)
Similarity:	104/217 - (47%)	Gaps:	31/217 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 CGGCILDAVTIATAAHCVYNRE-----AENFLVVAGDDSRGGMNGVVV-------RVSKLIPHEL 111
            ||..::.:..:.:||||...:.     ..||             |:||       :|..:|.||.
Human   210 CGASLISSRWLLSAAHCFAKKNNSKDWTVNF-------------GIVVNKPYMTRKVQNIIFHEN 261

  Fly   112 YNSSTMDNDIALVVVDPPLPLDSFSTMEAIEIASEQPAVGVQATISGWGYTKENGLSSDQLQQVK 176
            |:|..:.:|||||.:...:....:.....:..|..:.:......::|||....||.....||:..
Human   262 YSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDF 326

  Fly   177 VPIVDSEKCQEAY-YWRPISEGMLCAGLSEGGKDACQGDSGGPLVVANK-----LAGIVSWGEGC 235
            :.|:|::.|..:| |...:::.|||||...|..||||.||||||...:.     |.||||||:||
Human   327 LKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGC 391

  Fly   236 ARPNYPGVYANVAYYKDWIAKQ 257
            .:.|.||||..|..|::||..:
Human   392 GKKNKPGVYTRVTSYRNWITSK 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
etaTry	NP_523692.1	Tryp_SPc	27..254	CDD:214473	67/212 (32%)
etaTry	NP_523692.1	Tryp_SPc	28..257	CDD:238113	69/215 (32%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699
		Tryp_SPc	184..410	CDD:214473	67/212 (32%)
		Tryp_SPc	185..413	CDD:238113	69/215 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5783
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860