DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and PRSS12

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_003610.2	Gene:	PRSS12 / 8492	HGNCID:	9477	Length:	875	Species:	Homo sapiens

Alignment Length:	287	Identity:	88/287 - (30%)
Similarity:	125/287 - (43%)	Gaps:	66/287 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GLPLLEDLDEKSVPDGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAA 86
            ||.||....:      ||:||..:.....|:|:|||.|   :.....|..||.::.:...::|||
Human   620 GLRLLHRRQK------RIIGGKNSLRGGWPWQVSLRLK---SSHGDGRLLCGATLLSSCWVLTAA 675

  Fly    87 HCV--IGTVASQYKVVAG-------TNFQTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDP 142
            ||.  .|.....|.|..|       ..|:..     ..|::||:|..|....: :.|||::.:..
Human   676 HCFKRYGNSTRSYAVRVGDYHTLVPEEFEEE-----IGVQQIVIHREYRPDRS-DYDIALVRLQG 734

  Fly   143 P-----------LPLNNFTIKAIKLALEQPIEGTVSK--VSGWGTTSPGGYSSNQLLAVDVPIVS 194
            |           ||      ..:.|..|:| :.|.|.  ::|||.|  |...|..|....:|::.
Human   735 PEEQCARFSSHVLP------ACLPLWRERP-QKTASNCYITGWGDT--GRAYSRTLQQAAIPLLP 790

  Fly   195 NELCDQDYEDFGDETYRITSAMLCAG-----KRGVGGADACQGDSGGPLAVRDE-----LYGVVS 249
            ...|::.|:.      |.|..|||||     ||    .|:|||||||||.....     :|||.|
Human   791 KRFCEERYKG------RFTGRMLCAGNLHEHKR----VDSCQGDSGGPLMCERPGESWVVYGVTS 845

  Fly   250 WGNSCALPNYPGVYANVAYLRPWIDAV 276
            ||..|.:.:.||||..|:...|||.:|
Human   846 WGYGCGVKDSPGVYTKVSAFVPWIKSV 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	81/266 (30%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	82/268 (31%)
PRSS12	NP_003610.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..88
		KR	99..164	CDD:214527
		SR	170..270	CDD:214555
		SRCR	175..270	CDD:278931
		SR	280..380	CDD:214555
		SRCR	285..380	CDD:278931
		SR	387..486	CDD:214555
		SRCR	392..485	CDD:278931
		SR	500..599	CDD:214555
		SRCR	510..599	CDD:278931
		Zymogen activation region	619..630		4/15 (27%)
		Tryp_SPc	630..869	CDD:214473	81/266 (30%)
		Tryp_SPc	631..872	CDD:238113	82/268 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910