DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	251	Identity:	101/251 - (40%)
Similarity:	129/251 - (51%)	Gaps:	34/251 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIG---TVASQYKV 99
            |||||.:....:.|:|.|:..        .|||.||||:.....:||||||:..   ...|.::|
Human   217 RIVGGQSVAPGRWPWQASVAL--------GFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRV 273

  Fly   100 VAGTNFQTG---SDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNF--TIKAIKL-AL 158
            .||....:.   ..|.:  |:.|:.|. .||...::.|:|:|.:...|   ||  |:.|:.| |.
Human   274 HAGLVSHSAVRPHQGAL--VERIIPHP-LYSAQNHDYDVALLRLQTAL---NFSDTVGAVCLPAK 332

  Fly   159 EQPI-EGTVSKVSGWGTTSPG-GYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGK 221
            ||.. :|:...|||||.|.|. .|||:.|....||:.|.:||:......|    .:|..|||||.
Human   333 EQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSG----ALTPRMLCAGY 393

  Fly   222 RGVGGADACQGDSGGPLAVRD----ELYGVVSWGNSCALPNYPGVYANVAYLRPWI 273
            .. |.||||||||||||...|    .|.||||||..||.||:|||||.||....||
Human   394 LD-GRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	99/249 (40%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	100/250 (40%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133
		Tryp_SPc	217..448	CDD:214473	99/249 (40%)
		Tryp_SPc	218..451	CDD:238113	100/250 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910