DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and tmprss4a

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_005157547.1	Gene:	tmprss4a / 777630	ZFINID:	ZDB-GENE-061103-631	Length:	458	Species:	Danio rerio

Alignment Length:	258	Identity:	93/258 - (36%)
Similarity:	126/258 - (48%)	Gaps:	44/258 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIG---TVASQYKV 99
            |||||...|||..|:|:||:|.|        :|.||||:.....:||||||..|   ...|::.|
Zfish   223 RIVGGKDADIANWPWQVSLQYSG--------QHTCGGSLVTPNWVVTAAHCFNGDGRKALSRWTV 279

  Fly   100 VAGTNFQTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPP-----------LPLNNFTIKA 153
            |:|..:.:.:..  :.||||:::.. |..|..:.||.::.:..|           ||..|..:|.
Zfish   280 VSGITYLSSTPS--SYVKEIIVNSN-YKPAESDFDITMIKLQSPITLSESRRPVCLPPQNLGLKG 341

  Fly   154 IKLALEQPIEGTVSKVSGWG-TTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAML 217
                      |....|:||| ....||..|:.|....:.::.:..|... ..:|..   ||..|:
Zfish   342 ----------GDGLVVTGWGHMAEKGGSLSSMLQKAQIQVIDSAQCSSP-TVYGSS---ITPRMI 392

  Fly   218 CAGKRGVGGADACQGDSGGP---LAVRDELYGVVSWGNSCALPNYPGVYANVAYLRPWIDAVL 277
            |||.. .||.||||||||||   ||.|..|.||||||..||.|.:||||.||..:..|..:|:
Zfish   393 CAGVM-AGGVDACQGDSGGPLVHLADRWVLVGVVSWGVGCARPGFPGVYTNVDQMLDWAHSVM 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	91/252 (36%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	91/254 (36%)
tmprss4a	XP_005157547.1	LDLa	74..105	CDD:238060
		SRCR_2	121..218	CDD:295335
		Tryp_SPc	223..449	CDD:214473	91/251 (36%)
		Tryp_SPc	224..449	CDD:238113	90/250 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910