DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and C1S

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_001725.1	Gene:	C1S / 716	HGNCID:	1247	Length:	688	Species:	Homo sapiens

Alignment Length:	299	Identity:	86/299 - (28%)
Similarity:	134/299 - (44%)	Gaps:	56/299 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSWIVGLLAFLVSLVALTQGLPLLEDLDEKSVPDGRIVGGYATDIAQVPYQISLRYKGITTPEN 66
            :.||:..:|...:.......|:| .|..:||.    ||:||...||...|:|:..        :|
Human   406 NGSWVNEVLGPELPKCVPVCGVP-REPFEEKQ----RIIGGSDADIKNFPWQVFF--------DN 457

  Fly    67 PFRHRCGGSIFNETTIVTAAHCVIGT-VASQYKVVAGTNFQTG--SDGVITNVKEIVMHEGY--- 125
            |:   .||::.||..::||||.|.|. ..:.|  |..|:.||.  :...:...:.:.:|.|:
Human   458 PW---AGGALINEYWVLTAAHVVEGNREPTMY--VGSTSVQTSRLAKSKMLTPEHVFIHPGWKLL 517

  Fly   126 ---YSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQP--------IEGTVSKVSGWGTTSPGG 179
               .....::||||::.:..|:.:.. |:..|.|    |        ::|.:..:||||.|....
Human   518 EVPEGRTNFDNDIALVRLKDPVKMGP-TVSPICL----PGTSSDYNLMDGDLGLISGWGRTEKRD 577

  Fly   180 YSSNQLLAVDVPIVSNELCDQ---DYEDFGDETYRITSAMLCAGKRGVGGADACQGDSGGPLAVR 241
             .:.:|.|..:|:.....|.:   :......|.|..|..|:|||  |..|.|:|:|||||..||:
Human   578 -RAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAG--GEKGMDSCKGDSGGAFAVQ 639

  Fly   242 D-----ELY--GVVSWGNSCALPNYPGVYANVAYLRPWI 273
            |     :.|  |:||||..|.  .| |:|..|.....||
Human   640 DPNDKTKFYAAGLVSWGPQCG--TY-GLYTRVKNYVDWI 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	76/261 (29%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	77/262 (29%)
C1S	NP_001725.1	CUB	18..129	CDD:238001
		FXa_inhibition	143..171	CDD:405372
		CUB	175..287	CDD:395345
		CCP	294..355	CDD:153056
		Sushi	359..421	CDD:395037	3/14 (21%)
		Tryp_SPc	438..678	CDD:238113	77/262 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910