DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	259	Identity:	89/259 - (34%)
Similarity:	123/259 - (47%)	Gaps:	53/259 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVVAG 102
            |||||..:.::|.|:|.||:::|.        |.||||:.....|:||||||......:     .
Human   216 RIVGGNMSLLSQWPWQASLQFQGY--------HLCGGSVITPLWIITAAHCVYDLYLPK-----S 267

  Fly   103 TNFQTGSDGVITN------VKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQP 161
            ...|.|...::.|      |::||.| ..|......||||::.:..||..|.         :.||
Human   268 WTIQVGLVSLLDNPAPSHLVEKIVYH-SKYKPKRLGNDIALMKLAGPLTFNE---------MIQP 322

  Fly   162 I----------EGTVSKVSGWGTTSPG-GYSSNQLLAVDVPIVSNELCDQDYEDFGDETYR--IT 213
            :          :|.|...||||.|..| |.:|..|....||::||::|:.      .:.|.  |:
Human   323 VCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNH------RDVYGGIIS 381

  Fly   214 SAMLCAGKRGVGGADACQGDSGGPLAVRD----ELYGVVSWGNSCALPNYPGVYANVAYLRPWI 273
            .:|||||.. .||.|:|||||||||..::    :|.|..|:|..||..|.||||..|.....||
Human   382 PSMLCAGYL-TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	87/257 (34%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	88/258 (34%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133
		Tryp_SPc	216..444	CDD:214473	87/257 (34%)
		Tryp_SPc	217..447	CDD:238113	88/258 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910