DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and PRSS56

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	300	Identity:	86/300 - (28%)
Similarity:	127/300 - (42%)	Gaps:	43/300 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSWIVGLLAFLV---SLVALTQGLP----LLEDLDEK-------------SVPDGRIVGGYATD 46
            |:.|.:..:|..:   |......|.|    ||:|..|.             :...||||||.|..
Human    48 SAQWAINRVAMEIQHRSHECRGSGRPRPQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAP 112

  Fly    47 IAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVVAGTNFQTGSDG 111
            ....|:.:.|:..|     .|.   |||.:...:.::|||||.:|........|.......|...
Human   113 PGAWPWLVRLQLGG-----QPL---CGGVLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQA 169

  Fly   112 VITNVKEIVMHEGYYSGAAYNNDIAILFVDPPL-PLNNFTIKAIKLALEQPIEGTVSKVSGWGTT 175
            ....|..|:.|. .:....::||:|::.:..|: |..:.....:....::|..||...::|||..
Human   170 EEVPVNRILPHP-KFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGAL 233

  Fly   176 SPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGKRGVGGADACQGDSGGPLAV 240
            ...|..:..:....||::|.:.|.:   ..|....  .|.|||||.. .||.|:|||||||||..
Human   234 FEDGPEAEAVREARVPLLSTDTCRR---ALGPGLR--PSTMLCAGYL-AGGVDSCQGDSGGPLTC 292

  Fly   241 -------RDELYGVVSWGNSCALPNYPGVYANVAYLRPWI 273
                   |:.|:||.|||:.|..|..||||..||..:.|:
Human   293 SEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	74/242 (31%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	74/242 (31%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		7/31 (23%)
		Tryp_SPc	105..335	CDD:238113	74/242 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910