DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zetaTry and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	277	Identity:	94/277 - (33%)
Similarity:	135/277 - (48%)	Gaps:	51/277 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVSLVALTQGLPLLEDLDEKSVPDGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIF 77
            ||||..|..|         ||:...|:||.....:...|:|:|::|..        :|.|||||.
Human   188 LVSLHCLACG---------KSLKTPRVVGVEEASVDSWPWQVSIQYDK--------QHVCGGSIL 235

  Fly    78 NETTIVTAAHCV-IGTVASQYKVVAGTNFQTGSDGVITNVKEIVMHEGYYSGAAYN------NDI 135
            :...::|||||. ..|....:||.||:: :.||...:...|.|::.        :|      |||
Human   236 DPHWVLTAAHCFRKHTDVFNWKVRAGSD-KLGSFPSLAVAKIIIIE--------FNPMYPKDNDI 291

  Fly   136 AILFVDPPLPLNNFTIKAIKLAL--EQPIEGTVSKVSGWG-TTSPGGYSSNQLLAVDVPIVSNEL 197
            |::.:..||..:. |::.|.|..  |:....|...:.||| |...||..|:.||...|.::.:..
Human   292 ALMKLQFPLTFSG-TVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTR 355

  Fly   198 CDQDYEDFGDETYR--ITSAMLCAGKRGVGGADACQGDSGGPLAVRDE---LYGVVSWGNSCALP 257
            |:      .|:.|:  :|..|:||| ...||.|.|||||||||..:.:   :.|:||||..|..|
Human   356 CN------ADDAYQGEVTEKMMCAG-IPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGP 413

  Fly   258 NYPGVYANV-AYLRPWI 273
            :.||||..| |||. ||
Human   414 STPGVYTKVSAYLN-WI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	84/250 (34%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	85/251 (34%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	5/8 (63%)
		Tryp_SPc	204..429	CDD:214473	84/250 (34%)
		Tryp_SPc	205..432	CDD:238113	85/251 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910