DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and PRSS1

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	247	Identity:	92/247 - (37%)
Similarity:	123/247 - (49%)	Gaps:	27/247 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVV 100
            |.:|||||..:...||||:||         |...|.||||:.||..:|:|.||    ..|:.:|.
Human   246 DDKIVGGYNCEENSVPYQVSL---------NSGYHFCGGSLINEQWVVSAGHC----YKSRIQVR 297

  Fly   101 AGT-NFQT--GSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQPI 162
            .|. |.:.  |::..| |..:|:.|. .|.....||||.::.:.....: |..:..|.|....|.
Human   298 LGEHNIEVLEGNEQFI-NAAKIIRHP-QYDRKTLNNDIMLIKLSSRAVI-NARVSTISLPTAPPA 359

  Fly   163 EGTVSKVSGWG-TTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGKRGVGG 226
            .||...:|||| |.|.|....::|..:|.|::|...|:..|..      :|||.|.|.|.. .||
Human   360 TGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPG------KITSNMFCVGFL-EGG 417

  Fly   227 ADACQGDSGGPLAVRDELYGVVSWGNSCALPNYPGVYANVAYLRPWIDAVLA 278
            .|:||||||||:....:|.||||||:.||..|.||||..|.....||...:|
Human   418 KDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIA 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	88/238 (37%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	90/240 (38%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	88/238 (37%)
		Tryp_SPc	249..467	CDD:238113	90/240 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820