DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and tmprss2

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	258	Identity:	91/258 - (35%)
Similarity:	122/258 - (47%)	Gaps:	51/258 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RIVGGYATDIAQV-PYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVVA 101
            |||||.......| |:|:||.|.|        ||.|||||.....|:||||||     .|:....
Zfish   251 RIVGGTTVTSKGVWPWQVSLHYSG--------RHLCGGSIITPYWILTAAHCV-----HQFSNPG 302

  Fly   102 GTNFQTG---------SDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLA 157
            |.....|         :.|  .:|..||:|:  ::.....||||::.::..|.::. .|:.:.|
Zfish   303 GWTVYAGYLTQSEMASASG--NSVNRIVIHD--FNPNTNENDIALMRLNTALTIST-NIRPVCL- 361

  Fly   158 LEQPIEG---TVSK---VSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYR--ITS 214
               |.:|   |..:   |:|||....||.||..|....:.::.:.:|:      ....|.  ||.
Zfish   362 ---PNKGMSFTAQQDCYVTGWGALFSGGSSSATLQEAKIQLIDSTICN------SRPVYNGLITD 417

  Fly   215 AMLCAGKRGVGGADACQGDSGGPLAVRDE----LYGVVSWGNSCALPNYPGVYANVAYLRPWI 273
            .|:||||. .||.|:|||||||||.....    |.|..|||:.||:.|.||||.||.|...||
Zfish   418 TMICAGKL-AGGVDSCQGDSGGPLVTNVRSLWWLLGDTSWGDGCAVRNKPGVYGNVTYFLDWI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	89/256 (35%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	90/257 (35%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060
		SRCR_2	173..248	CDD:295335
		Tryp_SPc	251..479	CDD:214473	89/256 (35%)
		Tryp_SPc	252..482	CDD:238113	90/257 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910