DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and TMPRSS11F

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_997290.2	Gene:	TMPRSS11F / 389208	HGNCID:	29994	Length:	438	Species:	Homo sapiens

Alignment Length:	253	Identity:	87/253 - (34%)
Similarity:	125/253 - (49%)	Gaps:	42/253 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RIVGGYATDI-AQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVVA 101
            |||.|..|.: .:.|:|.||:..|       ..|:||.|:.:.|.::|||||.       :|...
Human   205 RIVQGRETAMEGEWPWQASLQLIG-------SGHQCGASLISNTWLLTAAHCF-------WKNKD 255

  Fly   102 GTNFQTGSDGVIT------NVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIK------AI 154
            .|.:.......||      ||::|::||.|:. ....||||::.:...:..:|...:      :|
Human   256 PTQWIATFGATITPPAVKRNVRKIILHENYHR-ETNENDIALVQLSTGVEFSNIVQRVCLPDSSI 319

  Fly   155 KLALEQPIEGTVSKVSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCA 219
            ||    |.:.:|. |:|:|:....|...|.|....|..:|.::|::  :|..|..  ||..||||
Human   320 KL----PPKTSVF-VTGFGSIVDDGPIQNTLRQARVETISTDVCNR--KDVYDGL--ITPGMLCA 375

  Fly   220 GKRGVGGADACQGDSGGPLAVRDE----LYGVVSWGNSCALPNYPGVYANVAYLRPWI 273
            |.. .|..|||:|||||||...:.    :.|:||||.|||||..||||..|...|.||
Human   376 GFM-EGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	85/251 (34%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	86/252 (34%)
TMPRSS11F	NP_997290.2	SEA	59..154	CDD:279699
		Tryp_SPc	205..432	CDD:214473	85/251 (34%)
		Tryp_SPc	206..435	CDD:238113	86/252 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910