DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and KLKB1

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	249	Identity:	93/249 - (37%)
Similarity:	131/249 - (52%)	Gaps:	30/249 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIG-TVASQYKVVA 101
            |||||..:...:.|:|:||:.| :|..    ||.||||:.....::|||||..| .:...:::.:
Human   401 RIVGGTNSSWGEWPWQVSLQVK-LTAQ----RHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYS 460

  Fly   102 G-TNF-QTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQPIEG 164
            | .|. ....|...:.:|||::|:.|..... |:|||::.:..||....|. |.|.|    |.:|
Human   461 GILNLSDITKDTPFSQIKEIIIHQNYKVSEG-NHDIALIKLQAPLNYTEFQ-KPICL----PSKG 519

  Fly   165 TVSK------VSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGKRG 223
            ..|.      |:|||.:...|...|.|..|::|:|:||.|.:.|:|     |:||..|:|||.:
Human   520 DTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQD-----YKITQRMVCAGYK- 578

  Fly   224 VGGADACQGDSGGPLAVRD----ELYGVVSWGNSCALPNYPGVYANVAYLRPWI 273
            .||.|||:|||||||..:.    .|.|:.|||..||....||||..||....||
Human   579 EGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	91/247 (37%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	92/248 (37%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	91/247 (37%)
		Tryp_SPc	402..632	CDD:238113	90/246 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910