DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and PRSS53

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	358	Identity:	84/358 - (23%)
Similarity:	126/358 - (35%)	Gaps:	122/358 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WIVGLLAFLVSLVALTQGLPLLEDLDEKSVP------DGRIVGGYATDIAQVPYQISLRYKGITT 63
            |..|.:..:.....|.:||...:....:..|      :|..|.|      :.|:|.|:|.:|
Human     3 WCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPG------EWPWQASVRRQG--- 58

  Fly    64 PENPFRHRCGGSIFNETTIVTAAHC---VIGTVASQYKVVAGTNFQTGSDGVITNVKEIVMHEGY 125
                 .|.|.||:..:|.::|||||   ...|..:.:.||.|:                :..||.
Human    59 -----AHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGS----------------LQREGL 102

  Fly   126 YSGA------------AYN-----NDIAILFVDPPLPLNNFTIKAIKLALEQPIEGTVSKVSGWG 173
            ..||            |||     :|:|:|.:..|       .....|.|.||........|.|.
Human   103 SPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHP-------TTHTPLCLPQPAHRFPFGASCWA 160

  Fly   174 T-----TSPG-------------------------GYSS-----NQLLA--------------VD 189
            |     ||.|                         |:.|     :|.||              :.
Human   161 TGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLR 225

  Fly   190 VPIVSNELCDQDYEDFGDE--TYRITSAMLCAGKR-GVGGADACQGDSGGP-LAVRDELY----G 246
            :.::|...|:..|......  :......|||.|.: ||.|  .|||||||| |.:..:.:    |
Human   226 LRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQG--PCQGDSGGPVLCLEPDGHWVQAG 288

  Fly   247 VVSWGNSCALPNYPGVYANVAYLRPWIDAVLAG 279
            ::|:.:|||..:.|.:..|.|....|:.|.:.|
Human   289 IISFASSCAQEDAPVLLTNTAAHSSWLQARVQG 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	74/311 (24%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	75/313 (24%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	75/312 (24%)
		Tryp_SPc	43..314	CDD:214473	74/309 (24%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030