DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and Tmprss6

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	257	Identity:	89/257 - (34%)
Similarity:	135/257 - (52%)	Gaps:	33/257 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PDGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCV-IGTVASQ-- 96
            |..|||||..:...:.|:|.||:.:|        ||.|||::..:..::|||||. ..::||.
  Rat   573 PSSRIVGGAMSSEGEWPWQASLQIRG--------RHICGGALIADRWVITAAHCFQEDSMASPRL 629

  Fly    97 YKVVAGTNFQTGS-DGVIT-NVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALE 159
            :.|..|...|... .|.:: .|..:.:|. |:...:::.|:|:|.:|.|: :.:.|::.:.|...
  Rat   630 WTVFLGKMRQNSRWPGEVSFKVSRLFLHP-YHEEDSHDYDVALLQLDHPV-VYSATVRPVCLPAR 692

  Fly   160 ----QPIEGTVSKVSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAG 220
                :|  |....::|||....||..|:.|..|||.::..:||::.|.      |::|..|||||
  Rat   693 SHFFEP--GQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAYR------YQVTPRMLCAG 749

  Fly   221 KRGVGGADACQGDSGGPLAVRDE-----LYGVVSWGNSCALPNYPGVYANVAYLRPWIDAVL 277
            .| .|..|||||||||||..::.     |.|:||||..|..||:.|||..|..:..||..||
  Rat   750 YR-KGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	84/248 (34%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	85/250 (34%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	84/248 (34%)
		Tryp_SPc	577..809	CDD:238113	85/250 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910