DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and TMPRSS12

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_872365.2	Gene:	TMPRSS12 / 283471	HGNCID:	28779	Length:	348	Species:	Homo sapiens

Alignment Length:	271	Identity:	80/271 - (29%)
Similarity:	125/271 - (46%)	Gaps:	56/271 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KSVPDG-RIVGGYATDIAQVPYQISLRYK-GITTPENPFRHRCGGSIFNETTIVTAAHC------ 88
            |.|..| ||:||........|:.:||:.| |     ....|.|||::..|..::|||||
Human    70 KDVLQGSRIIGGTEAQAGAWPWVVSLQIKYG-----RVLVHVCGGTLVRERWVLTAAHCTKDASD 129

  Fly    89 ------VIGT--VASQY----KVVAGTNFQTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVD 141
                  ||||  :..:|    |:               .:|.|::|..:.. .:|.||||:..:.
Human   130 PLMWTAVIGTNNIHGRYPHTKKI---------------KIKAIIIHPNFIL-ESYVNDIALFHLK 178

  Fly   142 PPLPLNNFTIKAIKLALE--QPIEG-TVSKVSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQDYE 203
            ..:..|:: |:.|.|..:  |.::| |...:||||.|...|.::|.|...:|..:|.|:|:.: .
Human   179 KAVRYNDY-IQPICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSE-R 241

  Fly   204 DFGDETYRITSAMLCAGKRGVGGADACQGDSGGPLAV------RDELYGVVSWGNSCALPNYPGV 262
            .:|.   .|.:...|||... |..|.|:|||||||..      |..:.|:.|:|:.|....:|||
Human   242 SYGG---IIPNTSFCAGDED-GAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGV 302

  Fly   263 YANVAYLRPWI 273
            |...::.:.|:
Human   303 YIGPSFYQKWL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	76/262 (29%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	76/263 (29%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..63
TMPRSS12	NP_872365.2	Tryp_SPc	78..316	CDD:238113	76/263 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910