DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zetaTry and PRSS55

DIOPT Version :9

Sequence 1:	NP_523691.1	Gene:	zetaTry / 36216	FlyBaseID:	FBgn0011556	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	305	Identity:	90/305 - (29%)
Similarity:	139/305 - (45%)	Gaps:	56/305 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVSLVALTQ----------GLPLL------------------EDLDEKSVPDG-----RIVGGYA 44
            |:|||..||          |:.:|                  .:..::|:.:|     ||.||..
Human     9 LLSLVTGTQLGPRTPLPEAGVAILGRARGAHRPQPPHPPSPVSECGDRSIFEGRTRYSRITGGME 73

  Fly    45 TDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIG--TVASQYKVVAGTNFQT 107
            .::.:.|:|:|::.:     ..||   |||||.|:..|:|||||:..  ....:..||.|||..|
Human    74 AEVGEFPWQVSIQAR-----SEPF---CGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLT 130

  Fly   108 GSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQPIEGTVSKVSGW 172
            .....|..|..|::|:. :..|..:||||:|.:..|:.|::..:.........|.......|:||
Human   131 SPSMEIKEVASIILHKD-FKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATWRECWVAGW 194

  Fly   173 GTTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGKRGVGGADACQGDSGGP 237
            |.|:....:|.:...:..|:|.     .|:|:......::|..|||||.:. ...|||:||||||
Human   195 GQTNAADKNSVKTDLMKAPMVI-----MDWEECSKMFPKLTKNMLCAGYKN-ESYDACKGDSGGP 253

  Fly   238 LAVRDE------LYGVVSWGNSCALPNYPGVYANVAYLRPWIDAV 276
            |....|      ..|::|||.||...|.||:|.::.....||:.|
Human   254 LVCTPEPGEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWIEKV 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	77/242 (32%)
zetaTry	NP_523691.1	Tryp_SPc	39..276	CDD:238113	78/244 (32%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	77/242 (32%)
		Tryp_SPc	68..298	CDD:238113	78/244 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910